Silylation with the Generation of a Fixed Charge for the Analysis of Alcohols by MALDI and SALDI Mass Spectrometry

被引：7
|
作者：
Zhilyaev, D. I. [1 ]
Voskresensky, L. G. [1 ]
Polovkov, N. Yu. [2 ]
Borisov, R. S. [1 ,2 ]
机构：
[1] Peoples Friendship Univ Russia, Moscow 117198, Russia
[2] Russian Acad Sci, Topchiev Inst Petrochem Synth, Moscow 119991, Russia
来源：
JOURNAL OF ANALYTICAL CHEMISTRY | 2018年 / 73卷 / 14期
关键词：
MALDI mass spectrometry; SALDI; alcohols; steroids; derivatization; fixed charge; DERIVATIZATION; PHENOLS;
D O I：
10.1134/S1061934818140149
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A new method of the derivatization of alcohols for their analysis by matrix-assisted laser desorption/ionization (MALDI) and surface-assisted laser desorption/ionization (SALDI) is proposed. The approach is based on the silylation of the analytes with bromomethylchlorodimethylsilane in the presence of tertiary amines to yield fixed-charge containing derivatives. The proposed method was tested using aliphatic alcohols, terpenols, and sterols. MALDI and SALDI mass spectra of all derivatives contain intense ion peaks corresponding to their cationic parts.
引用
收藏
页码：1323 / 1326
页数：4
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