Amplitude of Low-Frequency Oscillations in First-Episode Drug-Naive Patients with Major Depressive Disorder: A Resting State Functional Magnetic Resonance Imaging Study

被引：6

作者：

Zhang, Lulu ^{[1
]}

Wei, Xinghua ^{[2
]}

Zhao, Jingping ^{[3
,4
]}

机构：

[1] Guangzhou First Peoples Hosp, Dept Psychiat, 1 Panfu Rd, Guangzhou, Guangdong, Peoples R China

[2] Guangzhou First Peoples Hosp, Dept Med Imaging, Guangzhou, Guangdong, Peoples R China

[3] Cent South Univ, Dept Psychiat, Second Xiangya Hosp,Hunan Key Lab Psychiat & Ment, Chinese Natl Clin Res Ctr Mental Disorders,Chines, Changsha, Hunan, Peoples R China

[4] Cent South Univ, Mental Hlth Inst, Second Xiangya Hosp,Hunan Key Lab Psychiat & Ment, Chinese Natl Clin Res Ctr Mental Disorders,Chines, Changsha, Hunan, Peoples R China

来源：

NEUROPSYCHIATRIC DISEASE AND TREATMENT | 2022年 / 18卷

关键词：

major depressive disorder; first-episode; ALFF; fALFF; fMRI; SUBCLINICAL DEPRESSION; FLUCTUATION;

D O I：

10.2147/NDT.S348683

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objective: To observe characteristics of the amplitudes of low-frequency oscillation (LFO) in first-episode drug-naive patients with major depressive disorder (MDD). Methods: Amplitudes of low-frequency fluctuation (ALFF) and fractional ALFF (fALFF) were computed using resting-state functional magnetic resonance imaging (rs-fMRI) data of 39 first-episode drug-naive patients with MDD and 37 healthy controls. Results: ALFF and fALFF in the left cerebellum were significantly higher in patients with MDD compared to control group, while ALFF in the right rolandic operculum was significantly lower (all p < 0.001, AlphaSim correction). Conclusion: Abnormal neurological activity in multiple brain regions in first-episode drug-naive patients with MDD may be involved in the neurobiological mechanisms of MDD and should be considered in future studies.

引用

页码：555 / 561

页数：7

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