Polymorphisms in the interleukin-10 gene and hepatocellular carcinoma: an updated meta-analysis of 12 case-control studies

被引:0
作者
Zhang, Sheng [1 ]
Wang, Yafeng [2 ]
Liu, Chao [3 ]
Jiang, Jiakai [1 ]
Jiang, Heping [4 ]
Tang, Weifeng [3 ]
Chen, Yu [5 ,6 ]
Xiao, Zhenzhou [7 ]
机构
[1] Changzhou 3 Peoples Hosp, Dept Gen Surg, Changzhou, Jiangsu, Peoples R China
[2] Peoples Hosp Xishuangbanna Dai Autonomous Prefect, Dept Cardiol, Jinghong, Yunnan Province, Peoples R China
[3] Jiangsu Univ, Peoples Hosp, Dept Cardiothorac Surg, Zhenjiang, Jiangsu, Peoples R China
[4] Jiangsu Univ, Jintan Peoples Hosp, Dept Emergency, Jintan, Jiangsu, Peoples R China
[5] Fujian Med Univ, Canc Hosp, Fujian Prov Canc Hosp, Dept Med Oncol, Fuzhou 350014, Fujian Province, Peoples R China
[6] Fujian Prov Key Lab Translat Canc Med, Fuzhou 350014, Fujian Province, Peoples R China
[7] Fujian Med Univ, Canc Hosp, Fujian Prov Canc Hosp, Dept Clin Lab, Fuzhou 350014, Fujian Province, Peoples R China
来源
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE | 2016年 / 9卷 / 09期
关键词
Polymorphism; IL-10; hepatocellular carcinoma; susceptibility; meta-analysis; IL-10; POLYMORPHISMS; INCREASED RISK; COLORECTAL-CANCER; INTERFERON-GAMMA; ORAL-CANCER; TNF-ALPHA; ASSOCIATION; SUSCEPTIBILITY; HAPLOTYPE; SNP;
D O I
暂无
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Polymorphisms occurred in interleukin-10 (IL-10) gene may contribute to hepatocellular carcinoma (HCC) susceptibility. Since 2003, a number of epidemiological studies have explored the relationship between three common polymorphisms [ rs1800896 A>G (-1082 A>G), rs1800872 A>C (-592 A>C) and rs3021097 C>T (-819 C>T)] located on IL-10 gene and HCC risk; however, the results remain inconclusive. We carried out a meta-analysis of twelve case-control studies with 2,267 HCC cases and 3,994 controls to identify the correlation. Crude odds ratios (ORs) and their 95% confidence intervals (95% CIs) were harnessed to measure the strength of relationship. The findings indicated that IL-10-592 A>C polymorphism was associated with the risk of HCC in dominant genetic comparison model (CC+AC versus AA, fixed-effects OR = 1.18, 95% CI 1.04-1.35, P = 0.011). Begg's funnel plot and Egger's linear regression test were harnessed to assess the potential publication bias in our study. No obvious publication bias was found among the included studies. Results of one-way sensitivity analysis highlighted that our findings were robust. These results indicate that IL-10-592 A>C polymorphism conferred an increased risk for the development of HCC.
引用
收藏
页码:17140 / 17152
页数:13
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