Boron neutron capture therapy for clear cell sarcoma (CCS): Biodistribution study of p-borono-L-phenylalanine in CCS-bearing animal models

被引：16

作者：

Andoh, T. ^{[1
,2
]}

Fujimoto, T. ^{[3
]}

Sudo, T. ^{[4
]}

Fujita, I. ^{[3
]}

Imabori, M. ^{[3
]}

Moritake, H. ^{[5
]}

Sugimoto, T. ^{[6
]}

Sakuma, Y. ^{[7
]}

Takeuchi, T. ^{[8
]}

Kawabata, S. ^{[9
]}

Kirihata, M. ^{[10
]}

Akisue, T. ^{[11
]}

Yayama, K. ^{[2
,12
]}

Kurosaka, M. ^{[11
]}

Miyatake, S. ^{[9
]}

Fukumori, Y. ^{[1
,2
]}

Ichikawa, H. ^{[1
,2
]}

机构：

[1] Kobe Gakuin Univ, Pharmaceut Technol Lab, Fac Pharmaceut Sci, Kobe, Hyogo 6508586, Japan

[2] Kobe Gakuin Univ, Cooperat Res Ctr Life Sci, Kobe, Hyogo 6508586, Japan

[3] Hyogo Canc Ctr, Dept Orthopaed Surg, Akashi, Hyogo 6730021, Japan

[4] Hyogo Canc Ctr, Sect Translat Res, Akashi, Hyogo 6730021, Japan

[5] Miyazaki Univ, Dept Pediat, Kiyotake, Miyazaki 8891692, Japan

[6] Saiseikai Shigaken Hosp, Dept Pediat, Ritto 5203046, Japan

[7] Hyogo Canc Ctr, Dept Pathol, Akashi, Hyogo 6730021, Japan

[8] Kochi Univ, Dept Pathol, Nankoku 7838505, Japan

[9] Osaka Med Coll, Dept Neurosurg, Osaka 5698686, Japan

[10] Osaka Prefecture Univ, Grad Sch Life & Environm Sci, Sakai, Osaka 5998531, Japan

[11] Kobe Univ, Dept Orthopaed Surg, Grad Sch Med, Kobe, Hyogo 6500017, Japan

[12] Kobe Gakuin Univ, Lab Cardiovasc Pharmacol, Fac Pharmaceut Sci, Kobe, Hyogo 6508586, Japan

来源：

APPLIED RADIATION AND ISOTOPES | 2011年 / 69卷 / 12期

基金：

日本学术振兴会;

关键词：

Biodistribution; p-Borono-L-phenylalanine; Clear cell sarcoma; MP-CCS-SY; Boron neutron capture therapy; Anti-BPA monoclonal antibody; MALIGNANT-MELANOMA;

D O I：

10.1016/j.apradiso.2011.02.005

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Clear cell sarcoma (CCS) is a rare melanocytic malignant tumor with a poor prognosis. Our previous study demonstrated that in vitro cultured CCS cells have the ability to highly uptake L-BPA and thus boron neutron capture therapy could be a new option for CCS treatment. This paper proved that a remarkably high accumulation of (10)B (45-74 ppm) in tumor was obtained even in a CCS-bearing animal with a well-controlled biodistribution followed by intravenous administration of L-BPA-fructose complex (500 mg BPA/kg). (c) 2011 Elsevier Ltd. All rights reserved.

引用

页码：1721 / 1724

页数：4

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