MAGE-A3 expression is an adverse prognostic factor in diffuse large B-cell lymphoma

被引：12
|
作者：
Olarte, Irma [1 ]
Martinez, Adolfo [1 ]
Ramos-Penafiel, Christian [1 ]
Castellanos-Sinco, Humberto [1 ]
Zamora, Jorge [1 ]
Collazo-Jaloma, Juan [1 ]
Gutierrez, Mario [1 ]
Gutierrez-Kobeh, Laila [2 ]
Chavez-Olmos, Pedro [3 ]
Manzanilla, Hugo [4 ]
Garrido-Guerrero, Efrain [3 ]
Ordonez-Razo, Rosa M. [5 ]
Miranda, Enrique I. [1 ,6 ]
机构：
[1] Hosp Gen Mexico City, Serv Hematol, Lab Biol Mol, Mexico City 06726, DF, Mexico
[2] Univ Nacl Autonoma Mexico, Sch Med, Mexico City, DF, Mexico
[3] CINVESTAV IPN, Dept Genet & Biol Mol, Mexico City, DF, Mexico
[4] Hosp Gen Mexico City, Serv Urol, Mexico City 06726, DF, Mexico
[5] IMSS, Ctr Med Siglo 21, Hosp Pediat, Unidad Invest Med Genet Humana, Mexico City, DF, Mexico
[6] Westhill Univ, Sch Med, Mexico City, DF, Mexico
来源：
HEMATOLOGY | 2011年 / 16卷 / 06期
关键词：
MAGE-A3; Expression; Prognostic; DLBCL; Lymphoma; NON-HODGKINS-LYMPHOMA; TISSUE MICROARRAY; GENE-EXPRESSION; CANCER; CHEMOTHERAPY; PREDICTION; CARCINOMA; SURVIVAL; MYELOMA; ANTIGEN;
D O I：
10.1179/102453311X13085644680384
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
This study evaluates the prognostic value of MAGE-A3 expression in 28 diffuse large B-cell lymphoma (DLBCL) patients. A significant association was observed between MAGE-A3 expressions, assessed by quantitative real-time RT-polymerase chain reaction (PCR), with advanced stages of disease (P<0.05). Elevated serum lactate dehydrogenase (LDH) levels and International Prognostic Index (IPI) score were significantly higher in MAGE-A3-positive patients (P=0.025 and P=0.004, respectively). Expression of MAGE-A3 was associated with poor response to treatment and a significantly shorter overall survival (P<0.001). Our data address new information in the association of MAGE-A3 expression and poor prognosis in DLBCL patients.
引用
收藏
页码：368 / 372
页数：5
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