MAGE-A3 expression is an adverse prognostic factor in diffuse large B-cell lymphoma

被引：12

作者：

Olarte, Irma ^{[1
]}

Martinez, Adolfo ^{[1
]}

Ramos-Penafiel, Christian ^{[1
]}

Castellanos-Sinco, Humberto ^{[1
]}

Zamora, Jorge ^{[1
]}

Collazo-Jaloma, Juan ^{[1
]}

Gutierrez, Mario ^{[1
]}

Gutierrez-Kobeh, Laila ^{[2
]}

Chavez-Olmos, Pedro ^{[3
]}

Manzanilla, Hugo ^{[4
]}

Garrido-Guerrero, Efrain ^{[3
]}

Ordonez-Razo, Rosa M. ^{[5
]}

Miranda, Enrique I. ^{[1
,6
]}

机构：

[1] Hosp Gen Mexico City, Serv Hematol, Lab Biol Mol, Mexico City 06726, DF, Mexico

[2] Univ Nacl Autonoma Mexico, Sch Med, Mexico City, DF, Mexico

[3] CINVESTAV IPN, Dept Genet & Biol Mol, Mexico City, DF, Mexico

[4] Hosp Gen Mexico City, Serv Urol, Mexico City 06726, DF, Mexico

[5] IMSS, Ctr Med Siglo 21, Hosp Pediat, Unidad Invest Med Genet Humana, Mexico City, DF, Mexico

[6] Westhill Univ, Sch Med, Mexico City, DF, Mexico

来源：

HEMATOLOGY | 2011年 / 16卷 / 06期

关键词：

MAGE-A3; Expression; Prognostic; DLBCL; Lymphoma; NON-HODGKINS-LYMPHOMA; TISSUE MICROARRAY; GENE-EXPRESSION; CANCER; CHEMOTHERAPY; PREDICTION; CARCINOMA; SURVIVAL; MYELOMA; ANTIGEN;

D O I：

10.1179/102453311X13085644680384

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This study evaluates the prognostic value of MAGE-A3 expression in 28 diffuse large B-cell lymphoma (DLBCL) patients. A significant association was observed between MAGE-A3 expressions, assessed by quantitative real-time RT-polymerase chain reaction (PCR), with advanced stages of disease (P<0.05). Elevated serum lactate dehydrogenase (LDH) levels and International Prognostic Index (IPI) score were significantly higher in MAGE-A3-positive patients (P=0.025 and P=0.004, respectively). Expression of MAGE-A3 was associated with poor response to treatment and a significantly shorter overall survival (P<0.001). Our data address new information in the association of MAGE-A3 expression and poor prognosis in DLBCL patients.

引用

页码：368 / 372

页数：5

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