Titrated oxygen requirement and prognostication in idiopathic pulmonary fibrosis

被引：34

作者：

Hook, J. L. ^{[4
,5
]}

Arcasoy, S. M. ^{[4
,5
]}

Zemmel, D. ^{[4
,5
]}

Bartels, M. N. ^{[2
,4
,5
]}

Kawut, S. M. ^{[6
,7
,8
]}

Lederer, D. J. ^{[1
,3
,4
,5
]}

机构：

[1] Columbia Univ, Coll Phys & Surg, Div Pulm Allergy & Crit Care Med, Dept Med, New York, NY 10032 USA

[2] Columbia Univ, Coll Phys & Surg, Dept Rehabil & Regenerat Med, New York, NY 10032 USA

[3] Columbia Univ, Dept Epidemiol, Mailman Sch Publ Hlth, New York, NY USA

[4] New York Presbyterian Hosp Columbia, New York Presbyterian Lung Transplant Program, New York, NY USA

[5] New York Presbyterian Hosp Columbia, Interstitial Lung Dis Program, New York, NY USA

[6] Univ Penn, Sch Med, Penn Cardiovasc Inst, Philadelphia, PA 19104 USA

[7] Univ Penn, Sch Med, Dept Med, Philadelphia, PA 19104 USA

[8] Univ Penn, Sch Med, Ctr Clin Epidemiol & Biostat, Philadelphia, PA 19104 USA

来源：

EUROPEAN RESPIRATORY JOURNAL | 2012年 / 39卷 / 02期

基金：

美国国家卫生研究院;

关键词：

Idiopathic pulmonary fibrosis; interstitial lung diseases; outcome prediction; pulmonary fibrosis; pulmonary gas exchange; INTERSTITIAL LUNG-DISEASE; 6-MINUTE WALK TEST; SURVIVAL; PNEUMONIA; TRANSPLANTATION; HYPERTENSION; PERFORMANCE; MORTALITY; SYSTEM;

D O I：

10.1183/09031936.00108111

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

The supplemental oxygen flow rate is a common bedside measure of gas exchange impairment. We aimed to determine whether a titrated oxygen requirement (TOR) predicted mortality in idiopathic pulmonary fibrosis (IPF). We examined 104 adults with IPF enrolled in a prospective cohort study and a validation cohort of 151 adults with a variety of interstitial lung diseases (ILDs). The TOR was defined as the lowest oxygen flow rate required to maintain an oxyhaemoglobin saturation of 96% while standing. Cox proportional hazards models and time-dependent receiver operating characteristic curves were used to examine survival time. A higher TOR was associated with a greater mortality rate independent of forced vital capacity and 6-min walk test results in IPF (adjusted hazard ratio (per 1 L.min(-1)) 1.16, 95% CI 1.06-1.27). The TOR was at least as accurate as pulmonary function and 6-min walk testing at predicting 1-yr mortality. Findings were similar in other ILDs. The TOR is a simple, inexpensive bedside measurement that aids prognostication in IPF.

引用

页码：359 / 365

页数：7

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