MAVS Coordination of Antiviral Innate Immunity

被引：147

作者：

Vazquez, Christine ^{[1
]}

Horner, Stacy M. ^{[1
,2
]}

机构：

[1] Duke Univ, Med Ctr, Dept Mol Genet & Microbiol, Durham, NC 27708 USA

[2] Duke Univ, Med Ctr, Dept Med, Durham, NC 27710 USA

来源：

JOURNAL OF VIROLOGY | 2015年 / 89卷 / 14期

关键词：

RIG-I; PROTEIN; IDENTIFICATION; VARIANTS; PATHWAY;

D O I：

10.1128/JVI.01918-14

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

RNA virus infection is sensed in the cytoplasm by the retinoic acid-inducible gene I (RIG-I)-like receptors. These proteins signal through the host adaptor protein MAVS to trigger the antiviral innate immune response. Here, we describe how MAVS subcellular localization impacts its function and the regulation underlying MAVS signaling. We propose a model to describe how the coordination of MAVS functions at the interface between the mitochondria and the mitochondrion-associated endoplasmic reticulum (ER) membrane programs antiviral signaling.

引用

收藏

页码：6974 / 6977

页数：4

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