The role of the tumour microenvironment in immunotherapy

被引：74

作者：

Gasser, Stephan ^{[1
,2
]}

Lim, Lina H. K. ^{[3
]}

Cheung, Florence S. G. ^{[3
]}

机构：

[1] Roche Glycart AG, Roche Innovat Ctr Zurich, Roche Pharma Res & Early Dev, Schlieren, Switzerland

[2] Natl Univ Singapore, Ctr Life Sci, NUS Immunol Programme, Yong Loo Lin Sch Med,Dept Microbiol & Immunol, Singapore, Singapore

[3] Natl Univ Singapore, Ctr Life Sci, NUS Immunol Programme, Yong Loo Lin Sch Med,Dept Physiol, Singapore, Singapore

来源：

关键词：

pancreatic cancer; thyroid cancer; immunotherapy; tumour microenvironment; endometrial cancer; PAPILLARY THYROID-CANCER; PANCREATIC DUCTAL ADENOCARCINOMA; TOLL-LIKE RECEPTOR-3; REGULATORY T-CELLS; ADRENOCORTICAL CARCINOMA; MEMBRANE ANTIGEN; NK CELLS; CHECKPOINT BLOCKADE; ANTITUMOR-ACTIVITY; CROSS-PRESENTATION;

D O I：

10.1530/ERC-17-0146

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Recent success in immunomodulating strategies in lung cancer and melanoma has prompted much enthusiasm in their potential to treat other advanced solid malignancies. However, their applications have shown variable success and are even ineffective against some tumours. The efficiency of immunotherapies relies on an immunogenic tumour microenvironment. The current field of cancer immunology has focused on understanding the interaction of cancer and host immune cells to break the state of immune tolerance and explain how molecular patterns of cytokines and chemokines affect tumour progression. Here, we review our current knowledge of how inherent properties of tumours and their different tumour microenvironments affect therapeutic outcome. We also discuss insights into recent multimodal therapeutic approaches that target tumour immune evasion and suppression to restore anti-tumour immunity.

引用

页码：T283 / T295

页数：13

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