Exploring BAFF: its expression, receptors and contribution to the immunopathogenesis of Sjogren's syndrome

被引：65

作者：

Thompson, Nicolyn ^{[1
]}

Isenberg, David A. ^{[1
]}

Jury, Elizabeth C. ^{[1
]}

Ciurtin, Coziana ^{[1
]}

机构：

[1] UCL, Dept Med, Ctr Rheumatol Res, Rayne Bldg,5 Univ St, London W1CE 6JF, England

来源：

RHEUMATOLOGY | 2016年 / 55卷 / 09期

关键词：

B cell activating factor (BAFF); BAFF receptor; Sjogren's syndrome; CELL-ACTIVATING FACTOR; FACTOR FAMILY BAFF; B-CELL; TRANSGENIC MICE; LIPID RAFTS; SPLICE ISOFORM; DELTA-BAFF; SURVIVAL; MECHANISMS; APRIL;

D O I：

10.1093/rheumatology/kev420

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

SS is an autoimmune condition characterized by exocrine gland destruction, autoantibody production, immune complex deposition and systemic complications associated with lymphocytic infiltration of many organs. Genetic, environmental and viral factors play a role in disease aetiology, however, the exact mechanisms driving the immunopathogenesis of SS remain uncertain. Here we discuss a role for B cell activating factor (BAFF), whereby B cell hyperactivity and increased BAFF secretion observed in patients and animal models of the disease can be explained by the altered expression of cell-specific BAFF/BAFF receptor (BAFF-R) variants in several immune cell types. Understanding the role of BAFF/BAFF-R heterogeneity in SS pathogenesis could help to facilitate new treatment strategies for patients.

引用

页码：1548 / 1555

页数：8

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