Induction of podoplanin by transforming growth factor-β in human fibrosarcoma

被引：34
|
作者：
Suzuki, Hiroyuki [2 ]
Kato, Yukinari [1 ]
Kaneko, Mika Kato [1 ]
Okita, Yukari [2 ]
Narimatsu, Hisashi [1 ]
Kato, Mitsuyasu [2 ]
机构：
[1] Natl Inst Adv Ind Sci & Technol, Res Ctr Med Glycosci, Open Space Lab C 2, Tsukuba, Ibaraki 3058568, Japan
[2] Univ Tsukuba, Grad Sch Comprehens Human Sci, Dept Expt Pathol, Tsukuba 3058575, Japan
来源：
FEBS LETTERS | 2008年 / 582卷 / 02期
关键词：
podoplanin; platelet aggregation; TGF-beta; Smad; fibrosarcoma;
D O I：
10.1016/j.febslet.2007.12.028
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Podoplanin/aggrus is increased in tumors and its expression was associated with tumor malignancy. Podoplanin on cancer cells serves as a platelet-aggregating factor, which is associated with the metastatic potential. However, regulators of podoplanin remain to be determined. Transforming growth factor-beta (TGF-beta) regulates many physiological events, including tumorigenesis. Here, we found that TGF-beta induced podoplanin in human fibrosarcoma HT1080 cells and enhanced the platelet-aggregating-ability of HT1080. TGF-beta type I receptor inhibitor (SB431542) and short hairpin RNAs for Smad4 inhibited the podoplanin induction by TGF-beta. These results suggest that TGF-beta is a physiological regulator of podoplanin in tumor cells. (C) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码：341 / 345
页数：5
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