Tau: From research to clinical development

被引：103

作者：

Holtzman, David M. ^{[1
]}

Carrillo, Maria C. ^{[2
]}

Hendrix, James A. ^{[2
]}

Bain, Lisa J.

Catafau, Ana M. ^{[3
]}

Gault, Laura M. ^{[4
]}

Goedert, Michel ^{[5
]}

Mandelkow, Eckhard ^{[6
]}

Mandelkow, Eva-Maria ^{[6
]}

Miller, David S. ^{[7
]}

Ostrowitzki, Susanne ^{[8
]}

Polydoro, Manuela ^{[9
]}

Smith, Sean ^{[10
]}

Wittmann, Marion ^{[11
]}

Hutton, Michael ^{[12
]}

机构：

[1] Washington Univ, Knight Alzheimers Dis Res Ctr, Hope Ctr Neurol Disorders, Dept Neurol, St Louis, MO 63130 USA

[2] Alzheimers Assoc, Med & Sci Relat, Chicago, IL USA

[3] Piramal Imaging GmbH, Berlin, Germany

[4] AbbVie, N Chicago, IL USA

[5] MRC, Mol Biol Lab, Cambridge, England

[6] CAESAR Res Ctr, German Ctr Neurodegenerat Dis DZNE, Bonn, Germany

[7] Bracket Global, Wayne, PA USA

[8] F Hoffmann La Roche Ltd, Neurosci, Basel, Switzerland

[9] Novartis Inst Biomed Res, Cambridge, MA USA

[10] Merck, West Point, PA USA

[11] Biogen, Cambridge, MA USA

[12] Eli Lilly Inc, Windlesham, Surrey, England

来源：

ALZHEIMERS & DEMENTIA | 2016年 / 12卷 / 10期

关键词：

Tau; Alzheimer's disease; Biomarkers; Tauopathies; Neurofibrillary tangles; ALZHEIMERS-DISEASE; NEUROFIBRILLARY TANGLES; TRANSGENIC MICE; MOUSE MODEL; PROTEIN-TAU; O-GLCNAC; PATHOLOGY; AGGREGATION; ASSOCIATION; TAUOPATHY;

D O I：

10.1016/j.jalz.2016.03.018

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Alzheimer's Association Research Roundtable Fall 2015-Tau: From research to clinical development. Tau pathology is recognized as the key driver of disease progression in Alzheimer's and other neurodegenerative diseases. Although this makes tau an attractive target for the development of novel diagnostic and therapeutic strategies, the mechanisms underlying the onset and progression of tau-related neurotoxicity remain elusive. Recent strides in the development of sophisticated preclinical models and the emergence of tau PET imaging and fluid biomarkers provide new opportunities to increase our understanding of tau biology, overcome translational challenges, and accelerate the advancement of tau therapeutics from bench to bedside. With this in mind, the Alzheimer's Association convened a Research Roundtable in October 2015, bringing together experts from academia, industry, and regulatory agencies to discuss the latest understanding of tau pathogenic pathways and review the evolution of tau therapeutics and biomarkers currently in development. The meeting provided a forum to share experience and expertise with the common goal of advancing the discovery and development of new treatment strategies and expediting the design and implementation of efficient clinical trials. (C) 2016 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved.

引用

页码：1033 / 1039

页数：7

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