Current Progresses of Exosomes as Cancer Diagnostic and Prognostic Biomarkers

被引：189

作者：

Huang, Tao ^{[1
]}

Deng, Chu-Xia ^{[1
]}

机构：

[1] Univ Macau, Fac Hlth Sci, Macau, Peoples R China

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES | 2019年 / 15卷 / 01期

关键词：

exosomes; cancer; biomarkers; therapy; diagnosis; prognosis; CIRCULATING TUMOR-CELLS; LONG NONCODING RNA; BREAST-CANCER; EXTRACELLULAR VESICLES; PANCREATIC-CANCER; PROSTATE-CANCER; SERUM EXOSOMES; PROTEOMIC ANALYSIS; MELANOMA EXOSOMES; COLORECTAL-CANCER;

D O I：

10.7150/ijbs.27796

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cancer related exosomes are nano-size membrane vesicles that play important roles in tumor microenvironment. Emerging evidence indicates that exosomes can load unique cargoes, including proteins and nucleic acids that reflect the condition of tumor. Therefore, exosomes are being used as diagnostic and prognostic biomarkers for various cancers. In this review, we describe the current progresses of cancer related exosomes, including their biogenesis, molecular contents, biological functions, sources where they are derived from, and methods for their detection. We will also discuss the current exosomal biomarkers and the utilization of them for early diagnosis and prognostics in cancer.

引用

页码：1 / 11

页数：11

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