Design strategies for integrated protein purification processes: challenges, progress and outlook

被引：81

作者：

Nfor, Beckley K. ^{[1
]}

Ahamed, Tangir ^{[1
]}

van Dedem, Gijs W. K. ^{[1
]}

van der Wielen, Luuk A. M. ^{[1
]}

van de Sandt, Emile J. A. X. ^{[2
]}

Eppink, Michel H. M. ^{[3
]}

Ottens, Marcel ^{[1
]}

机构：

[1] Delft Univ Technol, Dept Biotechnol, Delft, Netherlands

[2] DSM Anti Infect, Delft, Netherlands

[3] NV Organon, Biotechnol Operat, Oss, Netherlands

来源：

JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY | 2008年 / 83卷 / 02期

关键词：

protein purification; process development; process synthesis; high throughput experimentation; expert systems; algorithmic approach;

D O I：

10.1002/jctb.1815

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The key to successful and efficient protein purification is the selection of the most appropriate purification techniques and their combination in a logical way to obtain the desired purification in the minimum number of steps. However, the rationalization of protein purification process development is faced with a number of challenges. In this paper, the challenges in protein purification process development are captured. The state-of-the-art in protein purification process synthesis and design is reviewed and the strengths and weaknesses of the current strategies highlighted. Finally, views on the future directions of protein purification process development are presented. (c) 2007 Society of Chemical Industry.

引用

页码：124 / 132

页数：9

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