Multivitamins, Individual Vitamin and Mineral Supplements, and Risk of Diabetes Among Older US Adults

被引:36
|
作者
Song, Yiqing [3 ]
Xu, Qun [1 ,2 ]
Park, Yikyung [4 ]
Hollenbeck, Albert [5 ]
Schatzkin, Arthur [4 ]
Chen, Honglei [1 ]
机构
[1] Natl Inst Environm Hlth Sci, Epidemiol Branch, Res Triangle Pk, NC USA
[2] Chinese Acad Med Sci, Inst Basic Med Sci, Dept Epidemiol & Hlth Stat, Beijing 100730, Peoples R China
[3] Harvard Univ, Brigham & Womens Hosp, Sch Med, Div Prevent Med, Boston, MA 02115 USA
[4] NCI, Nutr Epidemiol Branch, Rockville, MD USA
[5] Amer Assoc Retired Persons, Washington, DC USA
关键词
RANDOMIZED CONTROLLED-TRIAL; INSULIN-RESISTANCE; CARDIOVASCULAR-DISEASE; NATIONAL-INSTITUTES; DIETARY CALCIUM; HEALTH; WOMEN; ASSOCIATION; ANTIOXIDANT; POPULATION;
D O I
10.2337/dc10-1260
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
OBJECTIVE- Understanding the relationship between multivitamin use and diabetes risk is important given the wide use of multivitamin supplements among U.S. adults. RESEARCH DESIGN AND METHODS- We prospectively examined supplemental use of multivitamins and individual vitamins and minerals assessed in 1995-1996 in relation to self-reported diabetes diagnosed after 2000 among 232,007 participants in the National Institutes of Health American Association of Retired Persons Diet and Health Study. Multivitamin use was assessed by a food-frequency questionnaire at baseline. Odds ratios (ORs) and 95% CIs were calculated by logistic regression models, adjusted for potential confounders. In total, 14,130 cases of diabetes diagnosed after 2000 were included in the analysis. RESULTS- Frequent use of any multivitamins was not associated with risk of diabetes after adjustment for potential confounders and uses of individual supplements. Compared with nonusers of any multivitamins, the multivariate ORs among users were 1.07 (95% CI 0.94-1.21) for taking vitamins less than once per week, 0.97 (0.88-1.06) for one to three times per week, 0.92 (0.84-1.00) for four to six times per week, and 1.02 (0.98-1.06) for seven or more times per week (P for trend = 0.64). Significantly lower risk of diabetes was associated with the use of vitamin C or calcium supplements. The multivariate ORs comparing daily users with nonusers were 0.91 (0.86-0.97) for vitamin C supplements and 0.85 (0.80-0.90) for calcium supplements. Use of vitamin E or other individual vitamin and mineral supplements were not associated with diabetes risk. CONCLUSIONS- In this large cohort of U.S. older adults, multivitamin use was not associated with diabetes risk. The findings of lower diabetes risk among frequent users of vitamin C or calcium supplements warrant further evaluations.
引用
收藏
页码:108 / 114
页数:7
相关论文
共 50 条
  • [1] Use of Preventive Aspirin Among Older US Adults With and Without Diabetes
    Liu, Elizabeth Y.
    Al-Sofiani, Mohammed E.
    Yeh, Hsin-Chieh
    Echouffo-Tcheugui, Justin B.
    Joseph, Joshua J.
    Kalyani, Rita R.
    JAMA NETWORK OPEN, 2021, 4 (06) : E2112210
  • [2] The effects of vitamin D supplementation on frailty in older adults at risk for falls
    Cai, Yurun
    Wanigatunga, Amal A.
    Mitchell, Christine M.
    Urbanek, Jacek K.
    Miller, Edgar R.
    Juraschek, Stephen P.
    Michos, Erin D.
    Kalyani, Rita R.
    Roth, David L.
    Appel, Lawrence J.
    Schrack, Jennifer A.
    BMC GERIATRICS, 2022, 22 (01)
  • [3] Education, glucose control, and mortality risks among US older adults with diabetes
    Dupre, Matthew E.
    Silberberg, Mina
    Willis, Janese M.
    Feinglos, Mark N.
    DIABETES RESEARCH AND CLINICAL PRACTICE, 2015, 107 (03) : 392 - 399
  • [4] Mineral and vitamin consumption and telomere length among adults in the United States
    Mazidi, Mohsen
    Kengne, Andre-Pascal
    Banach, Maciej
    POLISH ARCHIVES OF INTERNAL MEDICINE-POLSKIE ARCHIWUM MEDYCYNY WEWNETRZNEJ, 2017, 127 (02): : 87 - 90
  • [5] Retirement and Epigenetic age Acceleration Among Older US Adults
    Das, Aniruddha
    ADAPTIVE HUMAN BEHAVIOR AND PHYSIOLOGY, 2023, 9 (03) : 264 - 283
  • [6] The effect of vitamin D and frailty on mortality among non-institutionalized US older adults
    Smit, E.
    Crespo, C. J.
    Michael, Y.
    Ramirez-Marrero, F. A.
    Brodowicz, G. R.
    Bartlett, S.
    Andersen, R. E.
    EUROPEAN JOURNAL OF CLINICAL NUTRITION, 2012, 66 (09) : 1024 - 1028
  • [7] Inflammation and poverty as individual and combined predictors of 15-year mortality risk in middle aged and older adults in the US
    Mainous III, Arch G.
    Orlando, Frank A.
    Yin, Lu
    Sharma, Pooja
    Wu, Velyn
    Saguil, Aaron
    FRONTIERS IN MEDICINE, 2024, 10
  • [8] Depression Among Older Adults with Diabetes in Israel: Pattern of Symptoms and Risk Factors
    Bashkin, Osnat
    ISRAEL MEDICAL ASSOCIATION JOURNAL, 2018, 20 (04): : 222 - 226
  • [9] Effectiveness of Vitamin D Supplements in Reducing the Risk of Falls among Older Adults: A Meta-Analysis of Randomized Controlled Trials
    Octary, Tiara
    Gautama, Made Satya Nugraha
    Duong, Hai
    ANNALS OF GERIATRIC MEDICINE AND RESEARCH, 2023, 27 (03): : 192 - 203
  • [10] Hearing Loss and Risk Factors among Community Dwelling Older Adults in Selangor
    Mukari, Siti Zamratol-Mai Sarah
    Maamor, Nashrah
    Ishak, Wan Syafira
    Hashim, Wan Fazlina Wan
    SAINS MALAYSIANA, 2016, 45 (09): : 1405 - 1411