Prediction of operons in microbial genomes

被引：212

作者：

Ermolaeva, MD ^{[1
]}

White, O ^{[1
]}

Salzberg, SL ^{[1
]}

机构：

[1] Inst Genom Res, Rockville, MD 20850 USA

来源：

NUCLEIC ACIDS RESEARCH | 2001年 / 29卷 / 05期

关键词：

D O I：

10.1093/nar/29.5.1216

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Operon structure is an important organization feature of bacterial genomes. Many sets of genes occur in the same order on multiple genomes; these conserved gene groupings represent candidate operons, This study describes a computational method: to estimate the likelihood that such conserved gene sets form operons. The method was used to-analyze 34 bacterial and archaeal genomes, and yielded more than 7600 pairs of genes that are highly likely (P greater than or equal to 0.98) to belong to the same operon. The sensitivity of our method is 30-50% for the Escherichia coli genome. The predicted gene pairs are available from our World Wide Web site http:// www.tigr.org/tigr-scripts/operons/operons.cgi.

引用

页码：1216 / 1221

页数：6

共 24 条

[1] Gapped BLAST and PSI-BLAST: a new generation of protein database search programs [J].