Synthesis and Structure-Activity Relationship of Active Vitamin D3 Analogues

被引：1

作者：

Hu Daihua ^{[1
]}

Wang, Chen ^{[1
]}

Wang Yongji ^{[1
]}

机构：

[1] Shaanxi Univ Technol, Vitamin Res Inst D, Hanzhong 723000, Peoples R China

来源：

PROGRESS IN CHEMISTRY | 2016年 / 28卷 / 06期

关键词：

1; alpha; 25-dihydroxyvitamin D-3; analogues; structure-activity relationship; chemical synthesis; biological activities; 1-ALPHA; 25-DIHYDROXYVITAMIN D-3 ANALOGS; HL-60; CELL-DIFFERENTIATION; BIOLOGICAL EVALUATION; SIDE-CHAINS; DESIGN; RING; DERIVATIVES; METABOLISM; AGONISTS; BINDING;

D O I：

10.7536/PC151226

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

1 alpha,25-Dihydroxyvitamin D-3 (1 alpha,25-(OH)(2)-D-3, 125D) is the most active metabolite of vitamin D-3, but the therapeutic application of 125D is limited by induction of hypercalcemia. The need for vitamin D compounds with selective biological profiles has stimulated the synthesis of more than three thousand analogues of 125D. This article reviews the recent progress of vitamin D research in the design and synthesis of the structural modifications in the A ring (including modification in the C2-, and C3-substitued, aromatic A ring and seco-A ring analogues), side chain, CD ring, seco-B ring, and non-secosteroidal vitamin D-3 analogs, and the relation between the structure and the biological activities.

引用

页码：839 / 859

页数：21

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