Leukotriene receptor antagonist pranlukast suppresses eosinophil infiltration and cytokine production in human nasal mucosa of perennial allergic rhinitis

被引：22

作者：

Ueda, T ^{[1
]}

Takeno, S ^{[1
]}

Furukido, K ^{[1
]}

Hirakawa, K ^{[1
]}

Yajin, K ^{[1
]}

机构：

[1] Hiroshima Univ, Grad Sch Biomed Sci, Div Clin Med Programs Appl Biomed, Dept Otorhinolaryngol Head & Neck Surg,Minami Ku, Hiroshima 7348551, Japan

来源：

ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY | 2003年 / 112卷 / 11期

关键词：

allergic rhinitis; cysteinyl leukotrienes; eosinophilic inflammation; pranlukast; T helper type 2 cytokine; Th2-type cytokine;

D O I：

10.1177/000348940311201107

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

The purpose of this study was to investigate the influence of pranlukast on eosinophilic inflammation and cytokine production in human nasal mucosa. Twelve patients were treated with pranlukast, and samples were obtained from the nasal mucosa of the inferior turbinate. With respect to cell infiltration, a significant decrease was observed in the percentage of inflammatory cells (secreted eosinophil cationic protein [EG2] and neutrophil elastase) after treatment. The levels of cytokines and chemical mediators (interleukin [IL]-4. IL-5. RANTES [regulated on activation, normal T cell expressed and secreted], cysteinyl leukotrienes, IL-1beta tumor necrosis factor-alpha and IL-8) assessed by enzyme-linked immunosorbent assay and enzyme immunoassay were significantly decreased. These results indicate that pranlukast decreased the levels of a majority of the cytokines in nasal mucosa, leading to improvement in subjective nasal symptoms. Furthermore, these results support the hypothesis that pranlukast exerts its therapeutic action primarily by blocking the leukotriene receptors on eosinophils.

引用

页码：955 / 961

页数：7

共 43 条

[1] Topical steroid treatment of allergic rhinitis decreases nasal fluid TH2 cytokines, eosinophils, eosinophil cationic protein, and IgE but has no significant effect on IFN-γ, IL-1β,TNF-α, or neutrophils [J].