The Molecular Basis and Therapeutic Aspects of Cisplatin Resistance in Oral Squamous Cell Carcinoma

被引:81
作者
Cheng, Yali [1 ,2 ]
Li, Shaoming [1 ,2 ]
Gao, Ling [1 ,3 ]
Zhi, Keqian [1 ,3 ]
Ren, Wenhao [1 ]
机构
[1] Qingdao Univ, Affiliated Hosp, Dept Oral & Maxillofacial Surg, Qingdao, Peoples R China
[2] Qingdao Univ, Sch Stomatol, Qingdao, Peoples R China
[3] Qingdao Univ, Affiliated Hosp, Key Lab Oral Clin Med, Qingdao, Peoples R China
关键词
oral squamous cell carcinoma; cisplatin; chemoresistance; molecular mechanisms; cancer therapy; RANDOMIZED PHASE-III; DOUBLE-EDGED-SWORD; INDUCTION CHEMOTHERAPY; DRUG-RESISTANCE; NECK-CANCER; UNRESECTABLE HEAD; MESENCHYMAL TRANSITION; PROMOTES PROLIFERATION; TONGUE CANCER; AUTOPHAGY;
D O I
10.3389/fonc.2021.761379
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Oral squamous cell carcinoma (OSCC) is a kind of malignant tumors with low survival rate and prone to have early metastasis and recurrence. Cisplatin is an alkylating agent which induces DNA damage through the formation of cisplatin-DNA adducts, leading to cell cycle arrest and apoptosis. In the management of advanced OSCC, cisplatin-based chemotherapy or chemoradiotherapy has been considered as the first-line treatment. Unfortunately, only a portion of OSCC patients can benefit from cisplatin treatment, both inherent resistance and acquired resistance greatly limit the efficacy of cisplatin and even cause treatment failure. Herein, this review outline the underlying mechanisms of cisplatin resistance in OSCC from the aspects of DNA damage and repair, epigenetic regulation, transport processes, programmed cell death and tumor microenvironment. In addition, this review summarizes the strategies applicable to overcome cisplatin resistance, which can provide new ideas to improve the clinical therapeutic outcome of OSCC.
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页数:16
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