Morphometric and cytological disturbances of pancreatic islets evoked by congenital portosystemic shunt in dogs

被引:2
作者
Frymus, J. [1 ]
Trebacz, P. [1 ]
Sobczak-Filipiak, M. [2 ]
Czopowicz, M. [3 ]
Galanty, M. [1 ]
机构
[1] Warsaw Univ Life Sci SGGW, Dept Small Anim Dis Clin, Nowoursynowska 159c, PL-02776 Warsaw, Poland
[2] Warsaw Univ Life Sci SGGW, Dept Pathol & Vet Diagnost, Nowoursynowska 159c, PL-02776 Warsaw, Poland
[3] Warsaw Univ Life Sci SGGW, Div Vet Epidemiol & Econ, Inst Vet Med, Nowoursynowska 159c, PL-02776 Warsaw, Poland
来源
POLISH JOURNAL OF VETERINARY SCIENCES | 2021年 / 24卷 / 04期
关键词
congenital portosystemic shunt; dogs; pancreatic islets; LIVER;
D O I
10.24425/pjvs.2021.139970
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
In 46 dogs with congenital portosystemic shunt (cPSS) histopathological examination of the pancreas, including measuring of the islet area, was performed, and the results were compared with those obtained in 6 control dogs without cPSS. Pancreatic islets were found in 43 (94%) dogs with cPSS and in all control animals. Mean area of the pancreatic islets was significantly lower in cPSS patients (median of 2219.4 mu m(2), interquartile range [IQR] from 1559.0 to 3146.2 mu m(2), range from 485.4 to 10333.4 mu m(2)) than in control dogs (median of 8705.5 mu m(2), IQR from 8284.4 to 9329.2 mu m(2), range from 7689.9 to 9624.2 mu m(2)) (p<0.001). The area of pan creatic islets was weakly, but significantly, positively correlated with the body weight of dogs (r=0.32, p=0.026), but not with the age or sex. Vacuoles were found in the cytoplasm of pan creatic islet cells in 37 (87%) dogs with cPSS and in none of the control animals (p<0.001). Their presence was not linked to the sex, breed, age or body weight. Extracellular homogenous eosinophilic, masses were present in pancreatic islets in 5 (12%) cPSS patients and in none of control animals. Connective tissue hyperplasia was found in pancreatic islets of 4 (9%) dogs with cPSS and in none of the control dogs. These results indicate that cPSS severely affects the pancreas, as shown by significantly reduced area of the islets, and the presence of eosinophilic masses in the pancreas and/or intracellular vacuoles.
引用
收藏
页码:465 / 471
页数:7
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