Natural Product Ligands of TRP Channels

被引：30

作者：

Vetter, Irina ^{[1
]}

Lewis, Richard J. ^{[1
]}

机构：

[1] Univ Queensland, Inst Mol Biosci, Brisbane, Qld 4072, Australia

来源：

TRANSIENT RECEPTOR POTENTIAL CHANNELS | 2011年 / 704卷

关键词：

VANILLOID RECEPTOR VR1; RAT DORSAL-ROOT; LINOLEIC-ACID METABOLITES; HEAT-EVOKED ACTIVATION; GATED ION-CHANNEL; CYCLIC ADP-RIBOSE; CAPSAICIN-RECEPTOR; CATION CHANNEL; SENSORY NEURONS; GANGLION NEURONS;

D O I：

10.1007/978-94-007-0265-3_3

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Natural product ligands have contributed significantly to the deorphanisation of TRP ion channels. Furthermore, natural product ligands continue to provide valuable leads for the identification of ligands acting at "orphan" TRP channels. Additional naturally occurring modulators at TRP channels can be expected to be discovered in future, aiding in our understanding of not only their pharmacology and physiology, but also the therapeutic potential of this fascinating family of ion channels.

引用

页码：41 / 85

页数：45

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