Combined Magnetic Hyperthermia and Immune Therapy for Primary and Metastatic Tumor Treatments

被引：216

作者：

Pan, Jiong ^{[2
]}

Hu, Ping ^{[1
]}

Guo, Yuedong ^{[1
]}

Hao, Junnian ^{[3
]}

Ni, Dalong ^{[1
]}

Xu, Yingying ^{[1
,4
]}

Bao, Qunqun ^{[1
,4
]}

Yao, Heliang ^{[1
]}

Wei, Chenyang ^{[1
]}

Wu, Qingsheng ^{[2
]}

Shi, Jianlin ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai, Peoples R China

[2] Tongji Univ, Sch Chem Sci & Engn, Shanghai 200092, Peoples R China

[3] Chongqing Med Univ, Affiliated Hosp 2, Ultrasound Dept, Chongqing Key Lab Ultrasound Mol Imaging, Chongqing 400010, Peoples R China

[4] ShanghaiTech Univ, Sch Phys Sci & Technol, Shanghai 201210, Peoples R China

来源：

ACS NANO | 2020年 / 14卷 / 01期

基金：

中国国家自然科学基金; 上海市自然科学基金;

关键词：

cancer; core-shell structure; magnetic hyperthermia therapy; checkpoint blockade immunotherapy; bilateral tumor model; PHOTOTHERMAL THERAPY; CHECKPOINT BLOCKADE; ACQUIRED-RESISTANCE; ANTITUMOR IMMUNITY; CANCER; IMMUNOTHERAPY; NANOPARTICLES; PD-L1; CRYOABLATION; COMBINATION;

D O I：

10.1021/acsnano.9b08550

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Cancer immunotherapy shows promising potential in future cancer treatment but unfortunately is clinically unsatisfactory due to the low therapeutic efficacy and the possible severe immunotoxicity. Here we show a combined magnetic hyperthermia therapy (MHT) and checkpoint blockade immunotherapy for both primary tumor ablation and mimetic metastatic tumor inhibition. Monodispersed, high-performance superparamagnetic CoFe2O4@MnFe2O4 nanoparticles were synthesized and used for effective MHT-induced thermal ablation of primary tumors. Simultaneously, numerous tumor-associated antigens were produced to promote the maturation and activation of dendritic cells (DCs) and cytotoxic T cells for effective immunotherapy of distant mimetic metastatic tumors in a tumor-bearing mice model. The combined MHT and checkpoint blockade immunotherapy demonstrate the great potentials in the fight against both primary and metastatic tumors.

引用

页码：1033 / 1044

页数：12

共 44 条

[1] Human T cell responses against melanoma [J].

Boon, Thierry ;

Coulie, Pierre G. ;

Van den Eynde, Benoit J. ;

van der Bruggen, Pierre .

ANNUAL REVIEW OF IMMUNOLOGY, 2006, 24 :175-208

[2] Safety and Activity of Anti-PD-L1 Antibody in Patients with Advanced Cancer [J].

Brahmer, Julie R. ;

Tykodi, Scott S. ;

Chow, Laura Q. M. ;

Hwu, Wen-Jen ;

Topalian, Suzanne L. ;

Hwu, Patrick ;

Drake, Charles G. ;

Camacho, Luis H. ;

Kauh, John ;

Odunsi, Kunle ;

Pitot, Henry C. ;

Hamid, Omid ;

Bhatia, Shailender ;

Martins, Renato ;

Eaton, Keith ;

Chen, Shuming ;

Salay, Theresa M. ;

Alaparthy, Suresh ;

Grosso, Joseph F. ;

Korman, Alan J. ;

Parker, Susan M. ;

Agrawal, Shruti ;

Goldberg, Stacie M. ;

Pardoll, Drew M. ;

Gupta, Ashok ;

Wigginton, Jon M. .

NEW ENGLAND JOURNAL OF MEDICINE, 2012, 366 (26) :2455-2465

[3] Prussian blue nanoparticle-based photothermal therapy combined with checkpoint inhibition for photothermal immunotherapy of neuroblastoma [J].

Cano-Mejia, Juliana ;

Burga, Rachel A. ;

Sweeney, Elizabeth E. ;

Fisher, John P. ;

Bollard, Catherine M. ;

Sandler, Anthony D. ;

Cruz, Conrad Russell Y. ;

Fernandes, Rohan .

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 2017, 13 (02) :771-781

[4] Iron Nanoparticles for Low-Power Local Magnetic Hyperthermia in Combination with Immune Checkpoint Blockade for Systemic Antitumor Therapy [J].

Chao, Yu ;

Chen, Guobin ;

Liang, Chao ;

Xu, Jun ;

Dong, Ziliang ;

Han, Xiao ;

Wang, Chao ;

Liu, Zhuang .

NANO LETTERS, 2019, 19 (07) :4287-4296

[5] Photothermal therapy with immune-adjuvant nanoparticles together with checkpoint blockade for effective cancer immunotherapy [J].

Chen, Qian ;

Xu, Ligeng ;

Liang, Chao ;

Wang, Chao ;

Peng, Rui ;

Liu, Zhuang .

NATURE COMMUNICATIONS, 2016, 7

[6] Blockade of B7-H1 improves myeloid dendritic cell-mediated antitumor immunity [J].

Curiel, TJ ;

Wei, S ;

Dong, HD ;

Alvarez, X ;

Cheng, P ;

Mottram, P ;

Krzysiek, R ;

Knutson, KL ;

Daniel, B ;

Zimmermann, MC ;

David, O ;

Burow, M ;

Gordon, A ;

Dhurandhar, N ;

Myers, L ;

Berggren, R ;

Hemminki, A ;

Alvarez, RD ;

Emilie, D ;

Curiel, DT ;

Chen, LP ;

Zou, WP .

NATURE MEDICINE, 2003, 9 (05) :562-567

[7] Study of Heating Efficiency as a Function of Concentration, Size, and Applied Field in γ-Fe2O3 Nanoparticles [J].

de la Presa, P. ;

Luengo, Y. ;

Multigner, M. ;

Costo, R. ;

Morales, M. P. ;

Rivero, G. ;

Hernando, A. .

JOURNAL OF PHYSICAL CHEMISTRY C, 2012, 116 (48) :25602-25610

[8] In situ tumor ablation creates an antigen source for the generation of antitumor immunity [J].

den Brok, MHMGM ;

Sutmuller, RPM ;

van der Voort, R ;

Bennink, EJ ;

Figdor, CG ;

Ruers, TJM ;

Adema, GJ .

CANCER RESEARCH, 2004, 64 (11) :4024-4029

[9] Irradiation and anti-PD-L1 treatment synergistically promote antitumor immunity in mice [J].

Deng, Liufu ;

Liang, Hua ;

Burnette, Byron ;

Beckett, Michael ;

Darga, Thomas ;

Weichselbaum, Ralph R. ;

Fu, Yang-Xin .

JOURNAL OF CLINICAL INVESTIGATION, 2014, 124 (02) :687-695

[10] Clinical significance of IgG Fc receptors and Fc gamma R-directed immunotherapies [J].

Deo, YM ;

Graziano, RF ;

Repp, R ;

vandeWinkel, JGJ .

IMMUNOLOGY TODAY, 1997, 18 (03) :127-135

← 1 2 3 4 5 →