Monoamine metabolism study in-severe, early-onset epilepsy in childhood

被引：3

作者：

Echenne, Bernard ^{[1
]}

Roubertie, Agathe ^{[1
]}

Leydet, Julie ^{[1
]}

Rivier, Francois ^{[1
]}

Hoffmann, Georg Friedrich ^{[2
]}

机构：

[1] Univ Montpellier, Child Neurol Dept, Montpellier, France

[2] Heidelberg Univ, Univ Kinder & Jugendmed, Heidelberg, Germany

来源：

EPILEPTIC DISORDERS | 2008年 / 10卷 / 02期

关键词：

neurotransmitters; monoamines; epilepsy; childhood;

D O I：

10.1684/epd.2008.0181

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Purpose. To investigate the possible dysfunction of monoamine metabolism in patients with early-onset, epileptic encephalopathies. Methods. The CSF dopamine, serotonin and biopterin metabolites were studied in 37 patients with severe, mostly drug-resistant epilepsy. Results. No significant abnormality was found, whatever the type of epilepsy, cryptogenic or symptomatic. Conclusions. The present study failed to demonstrate that dysfunction of the main neurotransmitters pathways is a common phenomenon in children with early-onset, severe epileptic encephalopathy.

引用

页码：130 / 135

页数：6

共 41 条

[1]

ALLAN AM, 1993, NEUROSCIENCE, V53, P425

[2] PROPOSAL FOR REVISED CLASSIFICATION OF EPILEPSIES AND EPILEPTIC SYNDROMES [J].

不详 .

EPILEPSIA, 1989, 30 (04) :389-399

[3] Approach to the diagnosis of neurotransmitter diseases exemplified by the differential diagnosis of childhood-onset dystonia [J].

Assmann, B ;

Surtees, R ;

Hoffmann, GF .

ANNALS OF NEUROLOGY, 2003, 54 :S18-S24

[4] Biogenic amines and pterins in cerebrospinal fluid: some pitfalls with interpretation [J].

Assmann, Birgit .

FUTURE NEUROLOGY, 2006, 1 (05) :651-657

[5] Serotonin and epilepsy [J].

Bagdy, Gyorgy ;

Kecskemeti, Valeria ;

Riba, Pal ;

Jakus, Rita .

JOURNAL OF NEUROCHEMISTRY, 2007, 100 (04) :857-873

[6] REGIONAL EFFECTS OF SODIUM VALPROATE ON EXTRACELLULAR CONCENTRATIONS OF 5-HYDROXYTRYPTAMINE, DOPAMINE, AND THEIR METABOLITES IN THE RAT-BRAIN - AN INVIVO MICRODIALYSIS STUDY [J].

BIGGS, CS ;

PEARCE, BR ;

FOWLER, LJ ;

WHITTON, PS .

JOURNAL OF NEUROCHEMISTRY, 1992, 59 (05) :1702-1708

[7] PET evidence for a role of the basal ganglia in patients with ring chromosome 20 epilepsy [J].

Biraben, A ;

Semah, F ;

Ribeiro, MJ ;

Douaud, G ;

Remy, P ;

Depaulis, A .

NEUROLOGY, 2004, 63 (01) :73-77

[8] Cerebrospinal fluid pterins and folates in Aicardi-Goutieres syndrome -: A new phenotype [J].

Blau, N ;

Bonafé, L ;

Krägeloh-Mann, I ;

Thöny, B ;

Kierat, L ;

Häusler, M ;

Ramaekers, V .

NEUROLOGY, 2003, 61 (05) :642-647

[9] Tetrahydrobiopterin deficiencies without hyperphenylalaninemia:: Diagnosis and genetics of DOPA-responsive dystonia and sepiapterin reductase deficiency [J].

Blau, N ;

Bonafé, L ;

Thöny, B .

MOLECULAR GENETICS AND METABOLISM, 2001, 74 (1-2) :172-185

[10]

BLAU N, INT DATABASE TETRAHY

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