Immunogenicity and protective efficacy against tuberculosis with DNA expressing ESAT6 protein

被引：3

作者：

Sang, Lin ^{[1
]}

Xiong, Guihua ^{[2
]}

Zhang, Hongxia ^{[3
]}

机构：

[1] Hosp Changchun Univ, Changchun 130022, Peoples R China

[2] Changchun Univ Chinese Med, Affiliated Hosp, Changchun 130021, Peoples R China

[3] Jilin Univ, China Japan Union Hosp, Changchun 130033, Peoples R China

来源：

AFRICAN JOURNAL OF MICROBIOLOGY RESEARCH | 2012年 / 6卷 / 02期

关键词：

Tuberculosis; Immunogenicity; ESAT6; humoral immune; cellular immune; BCG VACCINE; METAANALYSIS; IMMUNITY; BOVIS; MICE;

D O I：

10.5897/AJMR11.1376

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The greatest challenges in tuberculosis (TB) vaccine development include optimization of vaccines for use in humans, creation of effective single-dose vaccines, development of delivery systems that do not involve live viruses, and the identification of effective new adjuvants. In this study, we examined the immunogenicity and protective efficacy of DNA vaccine (pVAX1-ESAT6) expressing ESAT6 protein and its booster effects in mice for control tuberculosis. The results showed that ESAT6 DNA vaccine led to a dramatic augmentation of humoral and cellular responses. The novel immunogenic ESAT6 DNA vaccine revealed in this study provided a new candidate target for tuberculosis vaccine development.

引用

页码：431 / 435

页数：5

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