Immunogenicity and protective efficacy against tuberculosis with DNA expressing ESAT6 protein

被引：3
|
作者：
Sang, Lin [1 ]
Xiong, Guihua [2 ]
Zhang, Hongxia [3 ]
机构：
[1] Hosp Changchun Univ, Changchun 130022, Peoples R China
[2] Changchun Univ Chinese Med, Affiliated Hosp, Changchun 130021, Peoples R China
[3] Jilin Univ, China Japan Union Hosp, Changchun 130033, Peoples R China
来源：
AFRICAN JOURNAL OF MICROBIOLOGY RESEARCH | 2012年 / 6卷 / 02期
关键词：
Tuberculosis; Immunogenicity; ESAT6; humoral immune; cellular immune; BCG VACCINE; METAANALYSIS; IMMUNITY; BOVIS; MICE;
D O I：
10.5897/AJMR11.1376
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The greatest challenges in tuberculosis (TB) vaccine development include optimization of vaccines for use in humans, creation of effective single-dose vaccines, development of delivery systems that do not involve live viruses, and the identification of effective new adjuvants. In this study, we examined the immunogenicity and protective efficacy of DNA vaccine (pVAX1-ESAT6) expressing ESAT6 protein and its booster effects in mice for control tuberculosis. The results showed that ESAT6 DNA vaccine led to a dramatic augmentation of humoral and cellular responses. The novel immunogenic ESAT6 DNA vaccine revealed in this study provided a new candidate target for tuberculosis vaccine development.
引用
收藏
页码：431 / 435
页数：5
相关论文
共 50 条
  • [31] MPB64 DNA vaccine with immunogenicity and efficacy against tuberculosis
    Yao, Yunyi
    Hou, Qian
    Jin, Hua
    Lin, San
    Wang, Yajun
    Xue, Jianhong
    Sun, Li
    Hong, Huarong
    Zhou, Xiaoli
    Chen, Fang
    AFRICAN JOURNAL OF MICROBIOLOGY RESEARCH, 2012, 6 (07): : 1457 - 1462
  • [32] THE RECOMBINANT FUSION PROTEIN CFP10-ESAT6-DIFN HAS PROTECTIVE EFFECT AGAINST TUBERCULOSIS IN GUINEA PIGS
    Permyakova, Natalya V.
    Belavin, Pavel A.
    Pirozhkova, Dariya S.
    Ufimtseva, Elena G.
    Rozov, Sergey M.
    Mursalimov, Sergey R.
    Sidorchuk, Yuriy V.
    Uvarova, Elena A.
    Zagorskaya, Alla A.
    Marenkova, Tatiana V.
    Bannikova, Svetlana V.
    Demidov, Evgeniy A.
    Starostin, Konstantin V.
    Kravchenko, Marionella A.
    Vakhrusheva, Diana V.
    Berdnikov, Roman B.
    Eremeeva, Natalya I.
    Skornyakov, Sergey N.
    Peltek, Sergey E.
    Deineko, Elena V.
    ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA, 2018, 65 (01) : 39 - 58
  • [33] Immunogenicity and efficacy of a tuberculosis DNA vaccine
    Ulmer, JB
    Liu, MA
    Montgomery, DL
    Yawman, AM
    DeWitt, CM
    Deck, RR
    Denis, O
    Lozes, E
    Vandenbussche, P
    Content, J
    Huygen, K
    Drowart, A
    VanVooren, JP
    VACCINES 96 - MOLECULAR APPROACHES TO THE CONTROL OF INFECTIOUS DISEASES, 1996, : 39 - 43
  • [34] Differential protective efficacy of DNA vaccines expressing secreted proteins of Mycobacterium tuberculosis
    Kamath, AT
    Feng, CG
    Macdonald, M
    Briscoe, H
    Britton, WJ
    INFECTION AND IMMUNITY, 1999, 67 (04) : 1702 - 1707
  • [35] Improved humoral immunity against tuberculosis ESAT-6 antigen by chimeric DNA prime and protein boost strategy
    Li, ZM
    Song, D
    Zhang, HY
    He, W
    Fan, XY
    Zhang, Y
    Huang, JL
    Wang, XY
    Liu, QL
    Xiong, SD
    DNA AND CELL BIOLOGY, 2006, 25 (01) : 25 - 30
  • [36] Immunogenicity and protective efficacy of Ag85A and truncation of PstS1 fusion protein vaccines against tuberculosis
    Zeng, Lingyuan
    Ma, Xiuling
    Qu, Mengjin
    Tang, Minghui
    Li, Huoming
    Lei, Chengrui
    Ji, Jiahong
    Li, Hao
    HELIYON, 2024, 10 (05)
  • [37] Immunogenicity and protective efficacy of tuberculosis DNA vaccines encoding putative phosphate transport receptors
    Tanghe, A
    Lefèvre, P
    Denis, O
    D'Souza, S
    Braibant, M
    Lozes, E
    Singh, M
    Montgomery, D
    Content, J
    Huygen, K
    JOURNAL OF IMMUNOLOGY, 1999, 162 (02): : 1113 - 1119
  • [38] Study on immunogenicity and protective efficacy of tetravalent combination M-tuberculosis DNA vaccinea
    Gu, TY
    Cai, H
    Tian, X
    Yu, DH
    Zhu, YX
    PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS, 2005, 32 (04) : 347 - 352
  • [39] Immunogenicity and protective efficacy of a targeted fusion DNA construct against dental caries
    Xu, QA
    Yu, F
    Fan, MW
    Bian, Z
    Guo, JH
    Jia, R
    Chen, Z
    Peng, B
    Fan, B
    CARIES RESEARCH, 2005, 39 (05) : 422 - 431
  • [40] Improved Immunogenicity of Recombinant Mycobacterium bovis Bacillus Calmette-Guerin Strains Expressing Fusion Protein Ag85A-ESAT-6 of Mycobacterium tuberculosis
    Deng, Y. H.
    Sun, Z.
    Yang, X. L.
    Bao, L.
    SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 2010, 72 (04) : 332 - 338
12345