Synthesis of disulfide-based biodegradable bridged silsesquioxane nanoparticles for two-photon imaging and therapy of cancer cells

被引:61
作者
Croissant, Jonas G. [1 ]
Mauriello-Jimenez, Chiara [1 ]
Maynadier, Marie [3 ]
Cattoen, Xavier [4 ,5 ]
Man, Michel Wong Chi [1 ]
Raehm, Laurence [1 ]
Mongin, Olivier [6 ]
Blanchard-Desce, Mireille [7 ]
Garcia, Marcel [2 ]
Gary-Bobo, Magali [2 ]
Maillard, Philippe [8 ]
Durand, Jean-Olivier [1 ]
机构
[1] UMR 5253 CNRS UM ENSCM Cc 1701, Inst Charles Gerhardt Montpellier, F-34095 Montpellier 05, France
[2] CNRS, UM 2, UMR 5247, Inst Biomol Max Mousseron,UM 1,Fac Pharm, F-34093 Montpellier 05, France
[3] NanoMedSyn, F-34093 Montpellier 05, France
[4] CNRS, Inst Neel, F-38042 Grenoble, France
[5] Univ Grenoble Alpes, F-38042 Grenoble, France
[6] Univ Rennes 1, CNRS UMR 6226, Inst Sci Chim Rennes, F-35042 Rennes, France
[7] Univ Bordeaux, Inst Sci Mol, UMR CNRS 5255, F-33405 Talence, France
[8] Ctr Univ, Inst Curie, UMR 9187 U 1196, CMIB,CNRS INSERM, F-91405 Orsay, France
关键词
POLYSILSESQUIOXANE NANOPARTICLES; PHOTODYNAMIC THERAPY; DRUG; FLUORESCENCE; ABSORPTION; DELIVERY;
D O I
10.1039/c5cc03736k
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Biodegradable bridged silsesquioxane (BS) nanomaterials for two-photon-excited (TPE) imaging and therapy of breast cancer cells were described. A versatile synthesis was developed to design monodisperse tetra-alkoxysilylated diamino-diphenylbutadiene or Zn-porphyrin-based nanospheres of 30 to 50 nm.
引用
收藏
页码:12324 / 12327
页数:4
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