Lipid nanoparticles for brain targeting I. Formulation optimization

被引：46

作者：

Blasi, Paolo ^{[1
]}

Giovagnoli, Stefano ^{[1
]}

Schoubben, Aurelie ^{[1
]}

Puglia, Carmelo ^{[2
]}

Bonina, Francesco ^{[2
]}

Rossi, Carlo ^{[1
]}

Ricci, Maurizio ^{[1
]}

机构：

[1] Univ Perugia, Dipartimento Chim & Tecnol Farmaco, I-06123 Perugia, Italy

[2] Univ Catania, Dipartimento Sci Farmaceut, I-95125 Catania, Italy

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2011年 / 419卷 / 1-2期

关键词：

Lipid nanoparticles; Colloids; Blood-brain barrier; Neurovascular unit; Brain targeting; Response surface methodology; CENTRAL-NERVOUS-SYSTEM; THERMAL CHARACTERIZATION; DRUG-DELIVERY; X-RAY; BARRIER; CYTOTOXICITY; CALORIMETRY; MATRIX; RATS; SLN;

D O I：

10.1016/j.ijpharm.2011.07.035

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The aim of this study was to optimize the formulation of lipid nanoparticles (NPs), intended for brain targeting, with the aid of a computer generated experimental design. The high pressure homogenization technique, selected for this purpose, was suitable to formulate the 3 investigated lipids (i.e., Softisan (R) 142, SOFT; Compritol (R) 888 ATO, COMP; cetyl palmitate, CP) into nanometre-length particles, while the computer generated experimental design helped to individuate the best preparation conditions with a small number of experimental assay. Even though all the 3 optimized formulations were suitable for intravenous infusion, CP NPs showed the smallest particle size and the appropriate thermal behaviour to be used as carriers in brain targeting applications. (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：287 / 295

页数：9

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