Potential conflicts between economic growth and environmental degradation are central to the sustainable development debate. In this paper, we extend the previous analysis by developing a four-sector model of endogenous growth with horizontal innovations and non-renewable resources. We focus on how increasing non-renewable resource depletion and degradation, and endogenous technological progress affect long-run economic growth. First, we study the optimum in the planned economy compatible with our model, and we derive the solutions of the optimal equilibrium and a sufficient condition under which the sustainable growth path is both feasible and optimal; more specifically, we perform some comparative statics exercises to analyze the effects of parameter variations arising from the economic environment on the steady-state growth rate, and the stability of the dynamic economic system is also studied. Finally, we present some concluding remarks and discuss their policy implications.