Phosphodiesterases and subcellular compartmentalized cAMP signaling in the cardiovascular system

被引：60

作者：

Stangherlin, Alessandra ^{[1
]}

Zaccolo, Manuela ^{[1
]}

机构：

[1] Univ Glasgow, Mol Pharmacol Ctr, Inst Neurosci & Psychol, Coll Med Vet & Life Sci, Glasgow G12 8QQ, Lanark, Scotland

来源：

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY | 2012年 / 302卷 / 02期

关键词：

adenosine; 3; 5 '-cyclic monophosphate; compartmentalization; PROTEIN-KINASE-A; CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE; N-TERMINAL REGION; ENDOTHELIAL BARRIER FUNCTION; CHANNEL RYANODINE RECEPTOR; EPAC-MEDIATED ACTIVATION; EXCHANGE FACTOR EPAC2; ANCHORING PROTEIN; BINDING-PROTEIN; BETA-ARRESTIN;

D O I：

10.1152/ajpheart.00766.2011

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Stangherlin A, Zaccolo M. Phosphodiesterases and subcellular compartmentalized cAMP signaling in the cardiovascular system. Am J Physiol Heart Circ Physiol 302: H000-H000, 2012. First published October 28, 2011; doi: 10.1152/ajpheart.00766.2011.-Phosphodiesterases are key enzymes in the cAMP signaling cascade. They convert cAMP in its inactive form 5'-AMP and critically regulate the intensity and the duration of cAMP-mediated signals. Multiple isoforms exist that possess different intracellular distributions, different affinities for cAMP, and different catalytic and regulatory properties. This complex repertoire of enzymes provides a multiplicity of ways to modulate cAMP levels, to integrate more signaling pathways, and to respond to the specific needs of the cell within distinct subcellular domains. In this review we summarize key findings on phosphodiesterase compartmentalization in the cardiovascular system.

引用

页码：H379 / H390

页数：12

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