Dermal fibroblasts influence the expression profile of 14-3-3 proteins in human keratinocytes
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作者:
Carr, Matthew
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Univ British Columbia, BC Profess Firefighters Burn & Wound Healing Res, Dept Surg, Jack Bell Res Ctr, Vancouver, BC V6H 3Z6, CanadaUniv British Columbia, BC Profess Firefighters Burn & Wound Healing Res, Dept Surg, Jack Bell Res Ctr, Vancouver, BC V6H 3Z6, Canada
Carr, Matthew
[1
]
Chavez-Munoz, Claudia
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Univ British Columbia, BC Profess Firefighters Burn & Wound Healing Res, Dept Surg, Jack Bell Res Ctr, Vancouver, BC V6H 3Z6, CanadaUniv British Columbia, BC Profess Firefighters Burn & Wound Healing Res, Dept Surg, Jack Bell Res Ctr, Vancouver, BC V6H 3Z6, Canada
Chavez-Munoz, Claudia
[1
]
Lai, Amy
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Univ British Columbia, BC Profess Firefighters Burn & Wound Healing Res, Dept Surg, Jack Bell Res Ctr, Vancouver, BC V6H 3Z6, CanadaUniv British Columbia, BC Profess Firefighters Burn & Wound Healing Res, Dept Surg, Jack Bell Res Ctr, Vancouver, BC V6H 3Z6, Canada
Lai, Amy
[1
]
Ghahary, Aziz
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Univ British Columbia, BC Profess Firefighters Burn & Wound Healing Res, Dept Surg, Jack Bell Res Ctr, Vancouver, BC V6H 3Z6, CanadaUniv British Columbia, BC Profess Firefighters Burn & Wound Healing Res, Dept Surg, Jack Bell Res Ctr, Vancouver, BC V6H 3Z6, Canada
Ghahary, Aziz
[1
]
机构:
[1] Univ British Columbia, BC Profess Firefighters Burn & Wound Healing Res, Dept Surg, Jack Bell Res Ctr, Vancouver, BC V6H 3Z6, Canada
We have previously demonstrated that the release of some of the 14-3-3 isoforms from keratinocytes is able to influence the expression of key matrix metalloproteinases (MMPs) in dermal fibroblasts. Conversely, in this study we aimed to investigate whether dermal fibroblasts possess the ability to modulate the expression of 14-3-3 proteins in keratinocytes. In order to address this question, human keratinocytes and dermal fibroblasts were harvested and co-cultured. Intra- and extracellular levels of 14-3-3 proteins (beta, eta, gamma, and sigma) were analyzed using western blot analysis, and the gene expression was further assessed by quantitative real-time polymerase chain reaction. Gene analysis revealed an up-regulation of all four 14-3-3 isoforms of interest. In addition, the findings of this study reveal a significant increase in the intracellular levels of 14-3-3 gamma and sigma in keratinocytes co-cultured with fibroblasts compared to those of the mono-cultured control keratinocytes. Mechanistic investigations also demonstrated the capacity of several mitogen-activated protein kinase-specific inhibitors to markedly reduce induction of 14-3-3 sigma in keratinocytes stimulated with fibroblast-conditioned medium. The study concluded that dermal fibroblasts possess the ability to influence the expression of several 14-3-3 isoforms (notably gamma and sigma) in keratinocytes, suggesting that the two cell types might be capable of bi-directionally influencing the protein expression of one another in vivo.
机构:
Univ British Columbia, Jack Bell Res Ctr, BC Profess Burn & Wound Healing Res Lab, Dept Surg, Vancouver, BC V6H 3Z6, CanadaUniv British Columbia, Jack Bell Res Ctr, BC Profess Burn & Wound Healing Res Lab, Dept Surg, Vancouver, BC V6H 3Z6, Canada
Chavez-Munoz, Claudia
;
Morse, Jennifer
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Univ British Columbia, Jack Bell Res Ctr, BC Profess Burn & Wound Healing Res Lab, Dept Surg, Vancouver, BC V6H 3Z6, CanadaUniv British Columbia, Jack Bell Res Ctr, BC Profess Burn & Wound Healing Res Lab, Dept Surg, Vancouver, BC V6H 3Z6, Canada
Morse, Jennifer
;
Kilani, Ruhangiz
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Univ British Columbia, Jack Bell Res Ctr, BC Profess Burn & Wound Healing Res Lab, Dept Surg, Vancouver, BC V6H 3Z6, CanadaUniv British Columbia, Jack Bell Res Ctr, BC Profess Burn & Wound Healing Res Lab, Dept Surg, Vancouver, BC V6H 3Z6, Canada
Kilani, Ruhangiz
;
Ghahary, Aziz
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Univ British Columbia, Jack Bell Res Ctr, BC Profess Burn & Wound Healing Res Lab, Dept Surg, Vancouver, BC V6H 3Z6, CanadaUniv British Columbia, Jack Bell Res Ctr, BC Profess Burn & Wound Healing Res Lab, Dept Surg, Vancouver, BC V6H 3Z6, Canada
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Univ British Columbia, Dept Surg, BC Profess Burn & Wound Healing Res Lab, Jack Bell Res Ctr, Vancouver, BC V6H 3Z6, CanadaUniv British Columbia, Dept Surg, BC Profess Burn & Wound Healing Res Lab, Jack Bell Res Ctr, Vancouver, BC V6H 3Z6, Canada
Chavez-Munoz, Claudia
;
Kilani, Ruhangiz T.
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Univ British Columbia, Dept Surg, BC Profess Burn & Wound Healing Res Lab, Jack Bell Res Ctr, Vancouver, BC V6H 3Z6, CanadaUniv British Columbia, Dept Surg, BC Profess Burn & Wound Healing Res Lab, Jack Bell Res Ctr, Vancouver, BC V6H 3Z6, Canada
Kilani, Ruhangiz T.
;
Ghahary, Aziz
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Univ British Columbia, Dept Surg, BC Profess Burn & Wound Healing Res Lab, Jack Bell Res Ctr, Vancouver, BC V6H 3Z6, CanadaUniv British Columbia, Dept Surg, BC Profess Burn & Wound Healing Res Lab, Jack Bell Res Ctr, Vancouver, BC V6H 3Z6, Canada
机构:
Univ British Columbia, Jack Bell Res Ctr, Dept Surg, BC Profess Fire Fighters Burn & Wound Healing Lab, Vancouver, BC V6H 3Z6, CanadaUniv British Columbia, Jack Bell Res Ctr, Dept Surg, BC Profess Fire Fighters Burn & Wound Healing Lab, Vancouver, BC V6H 3Z6, Canada
Kilani, Ruhangiz T.
;
Medina, Abelardo
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Univ British Columbia, Jack Bell Res Ctr, Dept Surg, BC Profess Fire Fighters Burn & Wound Healing Lab, Vancouver, BC V6H 3Z6, CanadaUniv British Columbia, Jack Bell Res Ctr, Dept Surg, BC Profess Fire Fighters Burn & Wound Healing Lab, Vancouver, BC V6H 3Z6, Canada
Medina, Abelardo
;
Aitken, Alastair
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Univ Edinburgh, Sch Biol Sci, Edinburgh EH9 3JR, Midlothian, ScotlandUniv British Columbia, Jack Bell Res Ctr, Dept Surg, BC Profess Fire Fighters Burn & Wound Healing Lab, Vancouver, BC V6H 3Z6, Canada
Aitken, Alastair
;
Jalili, Reza B.
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Univ British Columbia, Jack Bell Res Ctr, Dept Surg, BC Profess Fire Fighters Burn & Wound Healing Lab, Vancouver, BC V6H 3Z6, CanadaUniv British Columbia, Jack Bell Res Ctr, Dept Surg, BC Profess Fire Fighters Burn & Wound Healing Lab, Vancouver, BC V6H 3Z6, Canada
Jalili, Reza B.
;
Carr, Matthew
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Univ British Columbia, Jack Bell Res Ctr, Dept Surg, BC Profess Fire Fighters Burn & Wound Healing Lab, Vancouver, BC V6H 3Z6, CanadaUniv British Columbia, Jack Bell Res Ctr, Dept Surg, BC Profess Fire Fighters Burn & Wound Healing Lab, Vancouver, BC V6H 3Z6, Canada
Carr, Matthew
;
Ghahary, Aziz
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h-index: 0
机构:
Univ British Columbia, Jack Bell Res Ctr, Dept Surg, BC Profess Fire Fighters Burn & Wound Healing Lab, Vancouver, BC V6H 3Z6, CanadaUniv British Columbia, Jack Bell Res Ctr, Dept Surg, BC Profess Fire Fighters Burn & Wound Healing Lab, Vancouver, BC V6H 3Z6, Canada
机构:
Univ British Columbia, Jack Bell Res Ctr, BC Profess Burn & Wound Healing Res Lab, Dept Surg, Vancouver, BC V6H 3Z6, CanadaUniv British Columbia, Jack Bell Res Ctr, BC Profess Burn & Wound Healing Res Lab, Dept Surg, Vancouver, BC V6H 3Z6, Canada
Chavez-Munoz, Claudia
;
Morse, Jennifer
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h-index: 0
机构:
Univ British Columbia, Jack Bell Res Ctr, BC Profess Burn & Wound Healing Res Lab, Dept Surg, Vancouver, BC V6H 3Z6, CanadaUniv British Columbia, Jack Bell Res Ctr, BC Profess Burn & Wound Healing Res Lab, Dept Surg, Vancouver, BC V6H 3Z6, Canada
Morse, Jennifer
;
Kilani, Ruhangiz
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h-index: 0
机构:
Univ British Columbia, Jack Bell Res Ctr, BC Profess Burn & Wound Healing Res Lab, Dept Surg, Vancouver, BC V6H 3Z6, CanadaUniv British Columbia, Jack Bell Res Ctr, BC Profess Burn & Wound Healing Res Lab, Dept Surg, Vancouver, BC V6H 3Z6, Canada
Kilani, Ruhangiz
;
Ghahary, Aziz
论文数: 0引用数: 0
h-index: 0
机构:
Univ British Columbia, Jack Bell Res Ctr, BC Profess Burn & Wound Healing Res Lab, Dept Surg, Vancouver, BC V6H 3Z6, CanadaUniv British Columbia, Jack Bell Res Ctr, BC Profess Burn & Wound Healing Res Lab, Dept Surg, Vancouver, BC V6H 3Z6, Canada
机构:
Univ British Columbia, Dept Surg, BC Profess Burn & Wound Healing Res Lab, Jack Bell Res Ctr, Vancouver, BC V6H 3Z6, CanadaUniv British Columbia, Dept Surg, BC Profess Burn & Wound Healing Res Lab, Jack Bell Res Ctr, Vancouver, BC V6H 3Z6, Canada
Chavez-Munoz, Claudia
;
Kilani, Ruhangiz T.
论文数: 0引用数: 0
h-index: 0
机构:
Univ British Columbia, Dept Surg, BC Profess Burn & Wound Healing Res Lab, Jack Bell Res Ctr, Vancouver, BC V6H 3Z6, CanadaUniv British Columbia, Dept Surg, BC Profess Burn & Wound Healing Res Lab, Jack Bell Res Ctr, Vancouver, BC V6H 3Z6, Canada
Kilani, Ruhangiz T.
;
Ghahary, Aziz
论文数: 0引用数: 0
h-index: 0
机构:
Univ British Columbia, Dept Surg, BC Profess Burn & Wound Healing Res Lab, Jack Bell Res Ctr, Vancouver, BC V6H 3Z6, CanadaUniv British Columbia, Dept Surg, BC Profess Burn & Wound Healing Res Lab, Jack Bell Res Ctr, Vancouver, BC V6H 3Z6, Canada
机构:
Univ British Columbia, Jack Bell Res Ctr, Dept Surg, BC Profess Fire Fighters Burn & Wound Healing Lab, Vancouver, BC V6H 3Z6, CanadaUniv British Columbia, Jack Bell Res Ctr, Dept Surg, BC Profess Fire Fighters Burn & Wound Healing Lab, Vancouver, BC V6H 3Z6, Canada
Kilani, Ruhangiz T.
;
Medina, Abelardo
论文数: 0引用数: 0
h-index: 0
机构:
Univ British Columbia, Jack Bell Res Ctr, Dept Surg, BC Profess Fire Fighters Burn & Wound Healing Lab, Vancouver, BC V6H 3Z6, CanadaUniv British Columbia, Jack Bell Res Ctr, Dept Surg, BC Profess Fire Fighters Burn & Wound Healing Lab, Vancouver, BC V6H 3Z6, Canada
Medina, Abelardo
;
Aitken, Alastair
论文数: 0引用数: 0
h-index: 0
机构:
Univ Edinburgh, Sch Biol Sci, Edinburgh EH9 3JR, Midlothian, ScotlandUniv British Columbia, Jack Bell Res Ctr, Dept Surg, BC Profess Fire Fighters Burn & Wound Healing Lab, Vancouver, BC V6H 3Z6, Canada
Aitken, Alastair
;
Jalili, Reza B.
论文数: 0引用数: 0
h-index: 0
机构:
Univ British Columbia, Jack Bell Res Ctr, Dept Surg, BC Profess Fire Fighters Burn & Wound Healing Lab, Vancouver, BC V6H 3Z6, CanadaUniv British Columbia, Jack Bell Res Ctr, Dept Surg, BC Profess Fire Fighters Burn & Wound Healing Lab, Vancouver, BC V6H 3Z6, Canada
Jalili, Reza B.
;
Carr, Matthew
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h-index: 0
机构:
Univ British Columbia, Jack Bell Res Ctr, Dept Surg, BC Profess Fire Fighters Burn & Wound Healing Lab, Vancouver, BC V6H 3Z6, CanadaUniv British Columbia, Jack Bell Res Ctr, Dept Surg, BC Profess Fire Fighters Burn & Wound Healing Lab, Vancouver, BC V6H 3Z6, Canada
Carr, Matthew
;
Ghahary, Aziz
论文数: 0引用数: 0
h-index: 0
机构:
Univ British Columbia, Jack Bell Res Ctr, Dept Surg, BC Profess Fire Fighters Burn & Wound Healing Lab, Vancouver, BC V6H 3Z6, CanadaUniv British Columbia, Jack Bell Res Ctr, Dept Surg, BC Profess Fire Fighters Burn & Wound Healing Lab, Vancouver, BC V6H 3Z6, Canada