Spirohydrazine rhodamine as a fluorescent chemodosimeter for the selective detection of Cu(II) ions and its application in live cell imaging

被引：35

作者：

Ren, Dandan ^{[1
]}

Liu, Yuan ^{[1
]}

Liu, Xiawei ^{[2
]}

Li, Zheng ^{[2
]}

Li, Hua ^{[1
]}

Yang, Xiao-Feng ^{[1
]}

机构：

[1] Northwest Univ, Coll Chem & Mat Sci, Minist Educ, Key Lab Synthet & Nat Funct Mol Chem, Xian 710069, Shaanxi, Peoples R China

[2] Northwest Univ, Coll Life Sci, Xian 710069, Shaanxi, Peoples R China

来源：

SENSORS AND ACTUATORS B-CHEMICAL | 2018年 / 255卷

基金：

中国国家自然科学基金;

关键词：

Chemodosimeter; Copper ions; Fluorescence; Rhodamine; Spirocycle; RECOGNITION PREFERENCE; COPPER DEFICIENCY; RATIONAL DESIGN; SI-RHODAMINE; CU2+; PROBE; OXIDATION; PLATFORM; SENSOR; PHENYLHYDRAZINE;

D O I：

10.1016/j.snb.2017.09.048

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A rhodamine-based fluorescent chemdosimeter SHR for Cu2+ has been developed based on the spirocyclic ring-opening mechanism. SHR is colorless and nonfluorescent due to intramolecular spirocyclization. Upon incubation with Cu2+ in aqueous media, a highly efficient ring opening of SHR occurs via Cu2+-promoted phenylhydrazine oxidation, causing a dual chromogenic and fluorogenic response. The fluorescent intensity at 580 nm increases linearly with Cu2+ concentration and as low as 10 nM of Cu2+ can be readily detected. The proposed chemodosimeter shows high selectivity toward Cu2+ over other metal ions and proves to be able to image Cu2+ levels in live cells. (C) 2017 Elsevier B.V. All rights reserved.

引用

页码：2321 / 2328

页数：8

共 68 条

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