Estimation of the Linearity of Ubidecarenone Pharmacokinetics After Intravenous Administration

被引：1

作者：

Kalenikova, E. I. ^{[1
]}

Gorodetskaya, E. A. ^{[1
]}

Belousova, M. A. ^{[1
]}

Kharitonova, E. V. ^{[1
]}

Tokareva, O. G. ^{[1
]}

Kulyak, O. Yu. ^{[1
]}

Medvedev, O. S. ^{[1
]}

机构：

[1] Moscow MV Lomonosov State Univ, Dept Fundamental Med, Moscow 119192, Russia

来源：

PHARMACEUTICAL CHEMISTRY JOURNAL | 2015年 / 48卷 / 12期

基金：

俄罗斯科学基金会;

关键词：

pharmacokinetics; coenzyme Q(10); COENZYME-Q10;

D O I：

10.1007/s11094-015-1193-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The dynamics of ubidecarenone (coenzyme Q(10)) levels in rat blood plasma and liver were monitored for two days after i.v. injection of solubilized ubidecarenone at doses of 10 and 30 mg/kg. The kinetic curves of the drug in plasma were exponential for both doses. The areas under the concentration-time curves differed by 8.6 times for the 10 and 30 mg/kg doses. Normalization to the dose did not superimpose them. The drug accumulated gradually in liver with the areas under the concentration-time curves differing by a factor of 4.4. These data indicated that ubidecarenone pharmacokinetics in plasma and liver were nonlinear after intravascular injection.

引用

页码：775 / 776

页数：2

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