AN INVESTIGATION TO THE IN SILICO DESIGN AND SYNTHESIS OF N-SUBSTITUTED AMINO THIOPHENES AS NOVEL CYCLOOXYGENASE-2 INHIBITORS

被引：0

作者：

Vysakh, C. C. ^{[1
]}

Hameed, Sherin A. ^{[1
]}

机构：

[1] Govt Med Coll, Coll Pharmaceut Sci, Dept Pharmaceut Chem, Trivandrum, Kerala, India

来源：

HETEROCYCLIC LETTERS | 2021年 / 11卷 / 04期

关键词：

In silico; Synthesis; 2-amino thiophene; COX-2; Anti inflammatory; DRUG DESIGN; DERIVATIVES;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2-Amino thiophene act as synthons for biologically active organic molecules. Computational screening performed on a series of 2-amino thiophene scaffolds and evaluated their potential to be a lead for development of novel drugs for the inhibition of Cyclooxygenase-2. Top ranked compounds were synthesized via modified Gewald's reaction and were characterized by physical and spectral methods.

引用

页码：559 / 567

页数：9

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