Biology of T memory type 1 cells

被引:59
作者
Anfossi, N
Pascal, V
Vivier, E
Ugolini, S
机构
[1] CNRS, Inst Pharmacol Mol & Cellulaire, F-06560 Sophia Antipolis, France
[2] Univ Med, CNRS Marseille Luminy, Ctr Immunol, INSERM, F-13288 Marseille, France
[3] Hop Conception, Hematol Serv, Marseille, France
关键词
D O I
10.1034/j.1600-065X.2001.1810123.x
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Engagement of inhibitory natural killer (NK) cell receptors for MHC class I molecules (NKR) can impair NK-cell activation programs. Inhibitory NKR thus confer to NK cells the capacity to discriminate between MHC class I+ and MHC class I- target cells, and are therefore involved in the control of NK-cell tolerance to self, as well as in the elimination of MHC class I- distressed cells by NK cells. In human and mouse, a subset of alpha beta T cells also express inhibitory NKR at their surface, but the biological function of inhibitory NKR on T cells remains to be precisely elucidated. We refer to these cells as T memory type 1 (Tm1) cells, and review here the phenotypic and functional features of this subset of memory-phenotype CD8(+) alpha beta T cells. in vitro studies suggest that inhibitory NKR are involved in the peripheral control of T-cell self-tolerance. In vitro and in vivo analysis have revealed a novel biological function for inhibitory NKR when expressed on T cells. Indeed, engagement of inhibitory NKR on T cells provides them with survival signals against activation-induced cell death. Thus, sensing of self-MHC class I molecules by inhibitory NKR displayed on alpha beta T cells leads to the in vivo accumulation of Tm 1 cells.
引用
收藏
页码:269 / 278
页数:10
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