Acetylator genotype in patients with Parkinson's and sporadic Alzheimer's disease

被引：0
|
作者：
Ji, Y [1 ]
Urakami, K [1 ]
Adachi, Y [1 ]
Kowa, H [1 ]
Nakashima, K [1 ]
机构：
[1] Tottori Univ, Fac Med, Inst Neurol Sci, Div Neurol, Yonago, Tottori 6838504, Japan
来源：
ALZHEIMERS REPORTS | 1998年 / 1卷 / 06期
关键词：
Alzheimer's disease; N-acetyltransferase; 2; Parkinson's disease; Japan;
D O I：
暂无
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
The acetylation polymorphism for N-acetyltransferase 2 (NAT2) is one of the most common genetic variations in the transformation of drugs and chemicals. NAT2 activity shows racial variation, suggesting its importance as a genetic factor. The etiopathogenesis of Alzheimer's disease (AD) and Parkinson's disease (PD) is considered to be multifactorial, including genetic and environmental factors. We determined the relationship between NAT2 genotypes in patients with PD and AD in a Japanese population. We found that there is no significant difference in the frequency of slow acetylator for NAT2 amongst AD, PD and elderly healthy controls. These results suggest that the NAT2 gene polymorphism is not a genetic risk factor for AD or PD in the Japanese.
引用
收藏
页码：361 / 363
页数：3
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