Synthesis of the dysiherbaine tetrahydropyran core utilizing improved tethered aminohydroxylation conditions

被引：10

作者：

Carroll, Christopher L. ^{[1
]}

Chamberlin, A. Richard ^{[1
]}

机构：

[1] Univ Calif Irvine, Dept Chem, Irvine, CA 92697 USA

来源：

TETRAHEDRON LETTERS | 2011年 / 52卷 / 31期

基金：

美国国家卫生研究院;

关键词：

SPONGE DYSIDEA-HERBACEA; AMINO-ACID; ASYMMETRIC AMINOHYDROXYLATION; (-)-DYSIHERBAINE; RECEPTORS;

D O I：

10.1016/j.tetlet.2011.05.106

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A concise stereoselective route to the dysiherbaine tetrahydropyran core was achieved in nine steps and 39% overall yield. Donohoe's improved tethered aminohydroxylation conditions were employed to concurrently install the amino and alcohol groups and construct the tetrahydropyran ring, which features four contiguous cis-stereocenters. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：3995 / 3997

页数：3

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