Acremonidins, new polyketide-derived antibiotics produced by Acremonium sp., LL-Cyan 416

被引：31

作者：

He, HY ^{[1
]}

Bigelis, R ^{[1
]}

Solum, EH ^{[1
]}

Greenstein, M ^{[1
]}

Carter, GT ^{[1
]}

机构：

[1] Wyeth Ayerst Res, Nat Prod Res, Chem & Screening Sci, Pearl River, NY 10965 USA

来源：

JOURNAL OF ANTIBIOTICS | 2003年 / 56卷 / 11期

关键词：

D O I：

10.7164/antibiotics.56.923

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Acremonidins A similar to E (1 similar to 5) were produced by fermentation of Acremonium sp., LL-Cyan 416, in heterogeneous phases. The structures of these compounds, containing a bridging keto group, were determined by spectroscopic analysis. Acremonidins A and B showed moderate activity against Gram-positive bacteria, including the methicillin-resistant staphylococci and vancomycin-resistant enterococci. Selective acylations of acremonidin B afforded ester derivatives 6 similar to 9 that exhibited improved antibacterial activity.

引用

页码：923 / 930

页数：8

共 11 条

[1]

BIGELIS R, 1999, ENCY LIFE SCI, P1

[2] Pyrrocidines A and B, new antibiotics produced by a filamentous fungus [J].

He, HY ;

Yang, HY ;

Bigelis, R ;

Solum, EH ;

Greenstein, M ;

Carter, GT .

TETRAHEDRON LETTERS, 2002, 43 (09) :1633-1636

[3] Mannopeptimycins, novel antibacterial glycopeptides from Streptomyces hygroscopicus, LL-AC98 [J].

He, HY ;

Williamson, RT ;

Shen, B ;

Graziani, EI ;

Yang, HY ;

Sakya, SM ;

Petersen, PJ ;

Carter, GT .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2002, 124 (33) :9729-9736

[4] Saccharomicins, novel heptadecaglycoside antibiotics effective against multidrug-resistant bacteria [J].

Kong, FM ;

Zhao, N ;

Siegel, MM ;

Janota, K ;

Ashcroft, JS ;

Koehn, FE ;

Borders, DB ;

Carter, GT .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1998, 120 (51) :13301-13311

[5]

NAGAO Y, 1981, CHEM PHARM BULL, V29, P3202

[6]

*NCCLS, 2000, METH DIL ANT SUSC TE, V19

[7] BIOSYNTHESIS OF PURPACTIN-A [J].

NISHIDA, H ;

TOMODA, H ;

OKUDA, S ;

OMURA, S .

JOURNAL OF ORGANIC CHEMISTRY, 1992, 57 (04) :1271-1274

[8] New developments in solid state fermentation: I-bioprocesses and products [J].

Pandey, A ;

Soccol, CR ;

Mitchell, D .

PROCESS BIOCHEMISTRY, 2000, 35 (10) :1153-1169

[9] STRUCTURE AND BIOSYNTHESIS OF XANTHOQUINODINS, ANTICOCCIDIAL ANTIBIOTICS [J].

TABATA, N ;

TOMODA, H ;

MATSUZAKI, K ;

OMURA, S .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1993, 115 (19) :8558-8564

[10] Xanthoquinodin B3, a new anticoccidial agent produced by Humicola sp FO-888 [J].

Tabata, N ;

Tomoda, H ;

Iwai, Y ;

Omura, S .

JOURNAL OF ANTIBIOTICS, 1996, 49 (03) :267-271

← 1 2 →