Cameroonian Spice Extracts Modulate Molecular Mechanisms Relevant to Cardiometabolic Diseases in SW 872 Human Liposarcoma Cells

被引：9

作者：

Atchan Nwakiban, Achille Parfait ^{[1
]}

Passarelli, Anna ^{[2
]}

Da Dalt, Lorenzo ^{[2
]}

Olivieri, Chiara ^{[2
]}

Demirci, Tugba Nur ^{[2
]}

Piazza, Stefano ^{[2
]}

Sangiovanni, Enrico ^{[2
]}

Carpentier-Maguire, Eugenie ^{[3
]}

Martinelli, Giulia ^{[2
]}

Shivashankara, Shilpa Talkad ^{[4
]}

Manjappara, Uma Venkateswaran ^{[4
]}

Tchamgoue, Armelle Deutou ^{[5
]}

Agbor, Gabriel Agbor ^{[5
]}

Kuiate, Jules-Roger ^{[1
]}

Daglia, Maria ^{[6
,7
]}

Dell'Agli, Mario ^{[2
]}

Magni, Paolo ^{[2
,8
]}

机构：

[1] Univ Dschang, Dept Biochem, Fac Sci, POB 96, Dschang, Cameroon

[2] Univ Milan, Dept Pharmacol & Biomol Sci, I-20133 Milan, Italy

[3] Univ Lille, Dept Sci & Technol, Rue Lille, F-59160 Lille, France

[4] CSIR Cent Food Technol Res Inst CFTRI, Dept Lipid Sci, Mysore 570020, Karnataka, India

[5] Inst Med Res & Med Plants Studies IMPM, Yaounde 4123, Cameroon

[6] Univ Naples Federico II, Dept Pharm, I-80131 Naples, Italy

[7] Jiangsu Univ, Int Res Ctr Food Nutr & Safety, Zhenjiang 212013, Jiangsu, Peoples R China

[8] IRCCS MultiMed, I-20099 Milan, Italy

来源：

NUTRIENTS | 2021年 / 13卷 / 12期

关键词：

Cameroonian spice extracts; SW; 872; adipocytes; triglyceride accumulation; glucose uptake; oxidative stress; pro-inflammatory cytokines; NF-KAPPA-B; ANTIINFLAMMATORY ACTIVITY; OXIDATIVE STRESS; ADIPOSE-TISSUE; IN-VITRO; OBESITY; ADIPOGENESIS; ADIPOCYTES; INHIBITION; ACID;

D O I：

10.3390/nu13124271

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

The molecular pathophysiology of cardiometabolic diseases is known to be influenced by dysfunctional ectopic adipose tissue. In addition to lifestyle improvements, these conditions may be managed by novel nutraceutical products. This study evaluatedthe effects of 11 Cameroonian medicinal spice extracts on triglyceride accumulation, glucose uptake, reactive oxygen species (ROS) production and interleukin secretion in SW 872 human adipocytes after differentiation with 100 mu M oleic acid. Triglyceride content was significantly reduced by all spice extracts. Glucose uptake was significantly increased by Tetrapleura tetraptera, Aframomum melegueta and Zanthoxylum leprieurii. Moreover, Xylopia parviflora, Echinops giganteus and Dichrostachys glomerata significantly reduced the production of ROS. Concerning pro-inflammatory cytokine secretion, we observed that Tetrapleura tetraptera, Echinops giganteus, Dichrostachys glomerata and Aframomum melegueta reduced IL-6 secretion. In addition, Xylopia parviflora, Monodora myristica, Zanthoxylum leprieurii, and Xylopia aethiopica reduced IL-8 secretion, while Dichrostachys glomerata and Aframomum citratum increased it. These findings highlight some interesting properties of these Cameroonian spice extracts in the modulation of cellular parameters relevant to cardiometabolic diseases, which may be further exploited, aiming to develop novel treatment options for these conditions based on nutraceutical products.

引用

页数：15

共 38 条

[1]

[Anonymous], Biological evaluation of medical devices - Part 5: Tests for in vitro cytotoxicity

[2] What Is the Best Strategy for Preclinical Testing of Botanicals? A Critical Perspective [J].

Butterweck, Veronika ;

Nahrstedt, Adolf .

PLANTA MEDICA, 2012, 78 (08) :747-754

[3] High Expression of Apolipoprotein E Impairs Lipid Storage and Promotes Cell Proliferation in Human Adipocytes [J].

Carmel, Jean-Francois ;

Tarnus, Evelyne ;

Cohn, Jeffrey S. ;

Bourdon, Emmanuel ;

Davignon, Jean ;

Bernier, Lise .

JOURNAL OF CELLULAR BIOCHEMISTRY, 2009, 106 (04) :608-617

[4] TNF-α and adipocyte biology [J].

Cawthorn, William P. ;

Sethi, Jaswinder K. .

FEBS LETTERS, 2008, 582 (01) :117-131

[5] Interactions of Oxysterols with Atherosclerosis Biomarkers in Subjects with Moderate Hypercholesterolemia and Effects of a Nutraceutical Combination (Bifidobacterium longum BB536, Red Yeast Rice Extract) (Randomized, Double-Blind, Placebo-Controlled Study) [J].

Cicolari, Stefania ;

Pavanello, Chiara ;

Olmastroni, Elena ;

Del Puppo, Marina ;

Bertolotti, Marco ;

Mombelli, Giuliana ;

Catapano, Alberico L. ;

Calabresi, Laura ;

Magni, Paolo .

NUTRIENTS, 2021, 13 (02) :1-15

[6] Hydromethanolic Extracts from Adansonia digitata L. Edible Parts Positively Modulate Pathophysiological Mechanisms Related to the Metabolic Syndrome [J].

Cicolari, Stefania ;

Dacrema, Marco ;

Tsetegho Sokeng, Arold Jorel ;

Xiao, Jianbo ;

Atchan Nwakiban, Achille Parfait ;

Di Giovanni, Carmen ;

Santarcangelo, Cristina ;

Magni, Paolo ;

Daglia, Maria .

MOLECULES, 2020, 25 (12)

[7] Dietary plant flavonoids in prevention of obesity and diabetes [J].

Dinda, Biswanath ;

Dinda, Manikarna ;

Roy, Arup ;

Dinda, Subhajit .

INFLAMMATORY DISORDERS - PT B, 2020, 120 :159-235

[8] Increased oxidative stress in obesity and its impact on metabolic syndrome [J].

Furukawa, S ;

Fujita, T ;

Shimabukuro, M ;

Iwaki, M ;

Yamada, Y ;

Nakajima, Y ;

Nakayama, O ;

Makishima, M ;

Matsuda, M ;

Shimomura, I .

JOURNAL OF CLINICAL INVESTIGATION, 2004, 114 (12) :1752-1761

[9] Chlorogenic acid attenuates lipopolysaccharide-induced mice mastitis by suppressing TLR4-mediated NF-κB signaling pathway [J].

Gao Ruifeng ;

Fu Yunhe ;

Wei Zhengkai ;

Zhou Ershun ;

Li Yimeng ;

Yao Minjun ;

Song Xiaojing ;

Yang Zhengtao ;

Zhang Naisheng .

EUROPEAN JOURNAL OF PHARMACOLOGY, 2014, 729 :54-58

[10] Comprehensive molecular characterization of human adipocytes reveals a transient brown phenotype [J].

Guennoun, Andrea ;

Kazantzis, Melissa ;

Thomas, Remy ;

Wabitsch, Martin ;

Tews, Daniel ;

Sastry, Konduru Seetharama ;

Abdelkarim, Mouaadh ;

Zilberfarb, Vladimir ;

Strosberg, Arthur Donny ;

Chouchane, Lotfi .

JOURNAL OF TRANSLATIONAL MEDICINE, 2015, 13

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