Emerging Role of Autophagy in the Development and Progression of Oral Squamous Cell Carcinoma

被引：17

作者：

Abd El-Aziz, Yomna S. ^{[1
,2
,3
]}

Leck, Lionel Y. W. ^{[1
,2
,4
]}

Jansson, Patric J. ^{[1
,2
,4
]}

Sahni, Sumit ^{[1
,2
]}

机构：

[1] Univ Sydney, Fac Med & Hlth, Sydney, NSW 2006, Australia

[2] Kolling Inst Med Res, Bill Walsh Translat Canc Res Lab, St Leonards, NSW 2064, Australia

[3] Tanta Univ, Fac Dent, Oral Pathol Dept, Tanta 31527, Egypt

[4] Univ Sydney, Canc Drug Resistance & Stem Cell Program, Sydney, NSW 2006, Australia

来源：

CANCERS | 2021年 / 13卷 / 24期

基金：

英国医学研究理事会;

关键词：

autophagy; oral squamous cell carcinoma; autophagy inhibitors; anti-cancer therapy; cancer progression; CANCER-ASSOCIATED FIBROBLASTS; HYPOXIA-INDUCED AUTOPHAGY; ADVANCED SOLID TUMORS; PHASE-I SAFETY; EXTRACELLULAR-MATRIX; INDUCED APOPTOSIS; ANOIKIS RESISTANCE; OXIDATIVE STRESS; C-MYC; MOLECULAR-MECHANISMS;

D O I：

10.3390/cancers13246152

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Simple Summary Autophagy is a stress responsive process which involves degradation of damaged cellular organelles to replenish the cell with the biomolecules required for its growth and survival. It has been linked to different type of pathologies including cancer. There is an emerging role of autophagy in oral cancer progression, which indicates that autophagy could be a candidate for therapeutic targeting. This review discusses the role autophagy plays in cancer progression, including oral cancer, and autophagy targeting as a potential therapeutic approach. Autophagy is a cellular catabolic process, which is characterized by degradation of damaged proteins and organelles needed to supply the cell with essential nutrients. At basal levels, autophagy is important to maintain cellular homeostasis and development. It is also a stress responsive process that allows the cells to survive when subjected to stressful conditions such as nutrient deprivation. Autophagy has been implicated in many pathologies including cancer. It is well established that autophagy plays a dual role in different cancer types. There is emerging role of autophagy in oral squamous cell carcinoma (OSCC) development and progression. This review will focus on the role played by autophagy in relation to different aspects of cancer progression and discuss recent studies exploring the role of autophagy in OSCC. It will further discuss potential therapeutic approaches to target autophagy in OSCC.

引用

页数：28

共 272 条

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