MTII attenuates ghrelin- and food deprivation-induced increases in food hoarding and food intake

被引:25
作者
Keen-Rhinehart, Erin [1 ,2 ]
Bartness, Timothy J. [1 ,2 ]
机构
[1] Georgia State Univ, Dept Biol, Atlanta, GA 30302 USA
[2] Georgia State Univ, Ctr Behav Neurosci, Atlanta, GA 30302 USA
关键词
fasting; foraging; melanotan II; hamster; Siberian hamster; intracerebroventricular;
D O I
10.1016/j.yhbeh.2007.07.014
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Food deprivation triggers a constellation of physiological and behavioral changes including increases in peripherally-produced ghrelin and centrally-produced agouti-related protein (AgRP). Upon refeeding, food intake is increased in most species, however hamsters primarily increase food hoarding. Food deprivation-induced increases in food hoarding by Siberian hamsters are mimicked by peripheral ghrelin and central AgRP injections. Because food deprivation stimulates ghrelin as well as AgRP synthesis/release, food deprivation-induced increases in hoarding may be mediated by melanocortin 3 or 4 receptor (MC3/4-R) antagonism via AgRP, the MC3/4-R inverse agonist. Therefore, we asked: Can a MC3/4-R agonist block food deprivation- or ghrelin-induced increases in foraging, food hoarding and food intake? This was accomplished by injecting melanotan II (MTII), a synthetic MC3/4-R agonist, into the 3rd ventricle in food deprived, fed or peripheral ghrelin injected hamsters and housed in a running wheel-based food delivery foraging system. Three foraging conditions were used: a) no running wheel access, non-contingent food, b) running wheel access, non-contingent food or c) a foraging requirement for food (10 revolutions/pellet). Food deprivation was a more potent stimulator of foraging and hoarding than ghrelin. Concurrent injections of MTII completely blocked food deprivation- and ghrelin-induced increases in food intake and attenuated, but did not always completely block, food deprivation- and ghrelin-induced increases in food hoarding. Collectively, these data suggest that the MC3/4-R are involved in ghrelin- and food deprivation-induced increases in food intake, but other neurochemical systems, such as previously demonstrated with neuropeptide Y, also are involved in increases in food hoarding as well as foraging. (C) 2007 Elsevier Inc. All rights reserved.
引用
收藏
页码:612 / 620
页数:9
相关论文
共 57 条
[1]   Stomach is a major source of circulating ghrelin, and feeding state determines plasma ghrelin-like immunoreactivity levels in humans [J].
Ariyasu, H ;
Takaya, K ;
Tagami, T ;
Ogawa, Y ;
Hosoda, K ;
Akamizu, T ;
Suda, M ;
Koh, T ;
Natsui, K ;
Toyooka, S ;
Shirakami, G ;
Usui, T ;
Shimatsu, A ;
Doi, K ;
Hosoda, H ;
Kojima, M ;
Kangawa, K ;
Nakao, K .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2001, 86 (10) :4753-4758
[2]   Ghrelin is an appetite-stimulatory signal from stomach with structural resemblance to motilin [J].
Asakawa, A ;
Inui, A ;
Kaga, T ;
Yuzuriha, H ;
Nagata, T ;
Ueno, N ;
Makino, S ;
Fujimiya, M ;
Niijima, A ;
Fujino, MA ;
Kasuga, M .
GASTROENTEROLOGY, 2001, 120 (02) :337-345
[3]  
Bartness T. J., 2004, FOOD FLUID INTAKE, V14, P423
[4]  
Bartness TJ, 2003, PROG PSYCHOB PHYSIOL, V18, P69
[5]   EFFECTS OF FOOD-DEPRIVATION AND RESTRICTION, AND METABOLIC BLOCKERS ON FOOD HOARDING IN SIBERIAN HAMSTERS [J].
BARTNESS, TJ ;
CLEIN, MR .
AMERICAN JOURNAL OF PHYSIOLOGY, 1994, 266 (04) :R1111-R1117
[6]   PHOTOPERIOD-PEPTIDE INTERACTIONS IN THE ENERGY-INTAKE OF SIBERIAN HAMSTERS [J].
BARTNESS, TJ ;
MORLEY, JE ;
LEVINE, AS .
PEPTIDES, 1986, 7 (06) :1079-1085
[7]   Food hoarding is increased by pregnancy, lactation, and food deprivation in Siberian hamsters [J].
Bartness, TJ .
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 1997, 272 (01) :R118-R125
[8]   Sympathetic innervation of white adipose tissue and its regulation of fat cell number [J].
Bowers, RR ;
Festuccia, WTL ;
Song, CK ;
Shi, HF ;
Migliorini, RH ;
Bartness, TJ .
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 2004, 286 (06) :R1167-R1175
[9]   ALTERED EXPRESSION OF HYPOTHALAMIC NEUROPEPTIDE MESSENGER-RNAS IN FOOD-RESTRICTED AND FOOD-DEPRIVED RATS [J].
BRADY, LS ;
SMITH, MA ;
GOLD, PW ;
HERKENHAM, M .
NEUROENDOCRINOLOGY, 1990, 52 (05) :441-447
[10]   The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis [J].
Cowley, MA ;
Smith, RG ;
Diano, S ;
Tschöp, M ;
Pronchuk, N ;
Grove, KL ;
Strasburger, CJ ;
Bidlingmaier, M ;
Esterman, M ;
Heiman, ML ;
Garcia-Segura, LM ;
Nillni, EA ;
Mendez, P ;
Low, MJ ;
Sotonyi, P ;
Friedman, JM ;
Liu, HY ;
Pinto, S ;
Colmers, WF ;
Cone, RD ;
Horvath, TL .
NEURON, 2003, 37 (04) :649-661