Current prospects and challenges in fish vaccine development in India with special reference to Aeromonas hydrophila vaccine

Infectious diseases are adversely affecting aquaculture practices throughout world and Asian countries are no exception. Indian aquaculture practices are facing serious setback due to a variety of infectious agents which are responsible for severe mortality and morbidity of all the cultured freshwater fish species leading to severe economic losses. The emergence of antibiotic resistant pattern, residual effect and environmental degradation due to indiscriminate use of antibiotics has necessitates the development of suitable alternate prophylaxis measures for better protection. In this regard, vaccine(s) has proved to be an effective strategy against pathogens to improve the fish production. Over the years numerous studies have been conducted to develop vaccine(s) against different pathogens. While most of the efforts are made to develop vaccine against bacterial pathogens especially against Aeromoniasis and Edwardsiellosis, few attempts have also been made against certain other bacterial, parasitic and fungal pathogens as well. Despite various successful experimental attempts, till date no vaccines against any of the pathogens are commercially available for Indian aquaculture. This review principally focuses on the current state of art in the development of vaccine against different microbial pathogens in general and Aeromonas hydrophila in particular since the bacterium is a major pathogen which is involved in a number of disease conditions in all the cultured fish species in India. Herein in this review, details of various experimental approaches made to find out a potential vaccine candidate which in turn can induce protective immune responses in host alongwith the constraints associated with it in developing a suitable vaccine against this bacterium and its market potential have been illustrated from an Indian perspective.