Advancement in the Development of Therapeutics Against Zika Virus Infection

被引：9

作者：

Li, Kangchen ^{[1
]}

Ji, Qianting ^{[1
]}

Jiang, Shibo ^{[2
,3
,4
]}

Zhang, Naru ^{[1
]}

机构：

[1] Zhejiang Univ City Coll, Sch Med, Dept Clin Med, Hangzhou, Peoples R China

[2] Fudan Univ, Natl Hlth Commiss NHC, Key Lab Med Mol Virol, Minist Educ MOE, Shanghai, Peoples R China

[3] Fudan Univ, Chinese Acad Med Sci CAMS, Sch Basic Med Sci, Shanghai, Peoples R China

[4] Fudan Univ, Shanghai Inst Infect Dis & Biosecur, Shanghai, Peoples R China

来源：

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY | 2022年 / 12卷

关键词：

Zika virus; pathogenesis; therapeutics; NS2B-NS3 protease inhibitors; NS3 protease inhibitors; NS5 protease inhibitors; E protein inhibitors; host protein inhibitors; NS2B-NS3; PROTEASE; ANTIVIRAL ACTIVITY; BROAD-SPECTRUM; INHIBITORS; DISCOVERY; PATHOGENESIS; REPLICATION; GENOME; DENGUE; DRUGS;

D O I：

10.3389/fcimb.2022.946957

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Zika virus (ZIKV), a re-emerging arbovirus, causes teratogenic effects on the fetus and normal nerve functions, resulting in harmful autoimmune responses, which call for the development of therapeutics against ZIKV infection. In this review, we introduce the pathogenesis of ZIKV infection and summarize the advancement in the development of therapeutics against ZIKV infection. It provides guidance for the development of effective therapeutics against ZIKV infection.

引用

页数：7

共 61 条

[1] Zika Virus Infection in Pregnancy, Microcephaly, and Maternal and Fetal Health [J].

Alvarado, Maria Gabriela ;

Schwartz, David A. .

ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE, 2017, 141 (01) :26-32

[2] Zika virus enhances monocyte adhesion and transmigration favoring viral dissemination to neural cells [J].

Ayala-Nunez, Nilda Vanesa ;

Follain, Gautier ;

Delalande, Franois ;

Hirschler, Aurlie ;

Partiot, Emma ;

Hale, Gillian L. ;

Bollweg, Brigid C. ;

Roels, Judith ;

Chazal, Maxime ;

Bakoa, Florian ;

Carocci, Margot ;

Bourdoulous, Sandrine ;

Faklaris, Orestis ;

Zaki, Sherif R. ;

Eckly, Anita ;

Uring-Lambert, Batrice ;

Doussau, Frdric ;

Cianferani, Sarah ;

Carapito, Christine ;

Jacobs, Frank M. J. ;

Jouvenet, Nolwenn ;

Goetz, Jacky G. ;

Gaudin, Raphael .

NATURE COMMUNICATIONS, 2019, 10 (1)

[3] Integrated MicroRNA and mRNA Profiling in Zika Virus-Infected Neurons [J].

Azouz, Francine ;

Arora, Komal ;

Krause, Keeton ;

Nerurkar, Vivek R. ;

Kumar, Mukesh .

VIRUSES-BASEL, 2019, 11 (02)

[4] Antiviral activities of selected antimalarials against dengue virus type 2 and Zika virus [J].

Balasubramanian, Anuradha ;

Teramoto, Tadahisa ;

Kulkarni, Amol A. ;

Bhattacharjee, Apurba K. ;

Padmanabhan, Radhakrishnan .

ANTIVIRAL RESEARCH, 2017, 137 :141-150

[5] Mechanism of Action of Methotrexate Against Zika Virus [J].

Beck, Sungjun ;

Zhu, Zhe ;

Oliveira, Michelli F. ;

Smith, Davey M. ;

Rich, Jeremy N. ;

Bernatchez, Jean A. ;

Siqueira-Neto, Jair L. .

VIRUSES-BASEL, 2019, 11 (04)

[6]

Best SM, 2017, J VIROL, V91, DOI [10.1128/JVI.01970-16, 10.1128/jvi.01970-16]

[7] Broad-spectrum agents for flaviviral infections: dengue, Zika and beyond [J].

Boldescu, Veaceslav ;

Behnam, Mira A. M. ;

Vasilakis, Nikos ;

Klein, Christian D. .

NATURE REVIEWS DRUG DISCOVERY, 2017, 16 (08) :565-586

[8] FLAVIVIRUS GENOME ORGANIZATION, EXPRESSION, AND REPLICATION [J].

CHAMBERS, TJ ;

HAHN, CS ;

GALLER, R ;

RICE, CM .

ANNUAL REVIEW OF MICROBIOLOGY, 1990, 44 :649-688

[9] The celecoxib derivative kinase inhibitor AR-12 (OSU-03012) inhibits Zika virus via down-regulation of the PI3K/Akt pathway and protects Zika virus infected A129 mice: A host-targeting treatment strategy [J].

Chan, Jasper Fuk-Woo ;

Zhu, Zheng ;

Chu, Hin ;

Yuan, Shuofeng ;

Chik, Kenn Ka-Heng ;

Chan, Chris Chung-Sing ;

Poon, Vincent Kwok-Man ;

Yip, Cyril Chik-Yan ;

Zhang, Xi ;

Tsang, Jessica Oi-Ling ;

Zou, Zijiao ;

Tee, Kah-Meng ;

Shuai, Huiping ;

Lu, Gang ;

Yuen, Kwok-Yung .

ANTIVIRAL RESEARCH, 2018, 160 :38-47

[10] Novel antiviral activity and mechanism of bromocriptine as a Zika virus NS2B-NS3 protease inhibitor [J].

Chan, Jasper Fuk-Woo ;

Chik, Kenn Ka-Heng ;

Yuan, Shuofeng ;

Yip, Cyril Chik-Yan ;

Zhu, Zheng ;

Tee, Kah-Meng ;

Tsang, Jessica Oi-Ling ;

Chan, Chris Chung-Sing ;

Poon, Vincent Kwok-Man ;

Lu, Gang ;

Zhang, Anna Jinxia ;

Lai, Kin-Kui ;

Chan, Kwok-Hung ;

Kao, Richard Yi-Tsun ;

Yuen, Kwok-Yung .

ANTIVIRAL RESEARCH, 2017, 141 :29-37

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