Effect of tissue inhibitor of metalloproteinases-3 genetics polymorphism on clinicopathological characteristics of uterine cervical cancer patients in Taiwan

被引：3
作者：
Chung, Jui-Fu [1 ,2 ]
Chen, Chia-Lin [3 ,4 ]
Nassef, Yasser [1 ]
Shiu, Bei-Hao [1 ,4 ,5 ]
Wang, Chun-Hao [6 ]
Kuo, Fu-Hsuan [1 ,7 ]
Hsiao, Yi-Hsuan [4 ,8 ]
Yang, Shun-Fa [1 ,9 ]
Wang, Po-Hui [1 ,3 ,4 ]
机构：
[1] Chung Shan Med Univ, Inst Med, 110,Sect 1,Chien Kuo North Rd, Taichung 40201, Taiwan
[2] Taichung Vet Gen Hosp, Dept Radiol, Taichung, Taiwan
[3] Chung Shan Med Univ Hosp, Dept Obstet & Gynecol, Taichung, Taiwan
[4] Chung Shan Med Univ, Sch Med, Taichung, Taiwan
[5] Chung Shan Med Univ Hosp, Dept Surg, Taichung, Taiwan
[6] Natl Taiwan Univ, Dept Med, Taipei, Taiwan
[7] Taichung Vet Gen Hosp, Neurol Inst, Taichung, Taiwan
[8] Changhua Christian Hosp, Dept Obstet & Gynecol, Changhua, Taiwan
[9] Chung Shan Med Univ Hosp, Dept Med Res, Taichung, Taiwan
来源：
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES | 2022年 / 19卷 / 06期
关键词：
tissue inhibitor of metalloproteinases-3; single nucleotide polymorphisms; uterine cervical cancer; lymph node metastasis; 5 years survival; MATRIX METALLOPROTEINASES; SUSCEPTIBILITY; INVASION; IMPACT;
D O I：
10.7150/ijms.72378
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Single nucleotide polymorphisms (SNPs) of tissue inhibitor of metalloproteinases-3 (TIMP-3) have been revealed to be related to various cancers. To date, no study explores the relationships between TIMP-3 polymorphisms and uterine cervical cancer. The purposes of this research were to investigate the associations among genetic variants of TIMP-3 and development and clinicopathological factors of uterine cervical cancer, and patient 5 years survival in Taiwanese women. The study included 123 patients with invasive cancer and 97 with precancerous lesions of uterine cervix, and 300 control women. TIMP-3 polymorphisms rs9619311, rs9862 and rs11547635 were checked and their genotypic distributions were determined by real-time polymerase chain reaction. It showed that women with genotypes CT/TT in rs9862 were found to display a higher risk of developing cervical cancer with moderate and poor cell differentiation. Moreover, it revealed that cervical cancer patients carrying genotypes CC in rs9619311 exhibited a poorer 5 years survival, as compared to those with TT/TC in Taiwanese women, using univariate analysis. In addition, pelvic lymph node metastasis was determined to independently predict 5 years survival in cervical cancer patients using multivariate analysis. Conclusively, TIMP-3 SNPs polymorphisms rs9619311 are related to cervical patient survival in Taiwanese women.
引用
收藏
页码：1013 / 1022
页数：10
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