Runx2 in normal tissues and cancer cells: A developing story

被引：82

作者：

Blyth, Karen ^{[1
]}

Vaillant, Francois ^{[2
]}

Jenkins, Alma ^{[2
]}

McDonald, Laura ^{[1
]}

Pringle, Marie Anne ^{[3
]}

Huser, Camille ^{[3
]}

Stein, Torsten ^{[3
]}

Neil, James ^{[2
]}

Cameron, Ewan R. ^{[2
]}

机构：

[1] Beatson Inst Canc Res, Glasgow G61 1BD, Lanark, Scotland

[2] Univ Glasgow, Inst Comparat Med, Fac Vet Med, Glasgow G61 1QH, Lanark, Scotland

[3] Univ Glasgow, Div Canc Sci & Mol Pathol, Glasgow G11 6NT, Lanark, Scotland

来源：

BLOOD CELLS MOLECULES AND DISEASES | 2010年 / 45卷 / 02期

关键词：

Runx; Haematopoietic; Mammary; Prostate; Oncogene; ACUTE MYELOID-LEUKEMIA; TRANSCRIPTION FACTOR RUNX2; MAMMARY EPITHELIAL-CELLS; GENE-EXPRESSION; BREAST-CANCER; IN-VIVO; OSTEOBLAST DIFFERENTIATION; STEM-CELLS; SURVIVIN EXPRESSION; ADULT HEMATOPOIESIS;

D O I：

10.1016/j.bcmd.2010.05.007

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The Runx transcription factors are essential for mammalian development, most notably in the haematopoietic and osteogenic lineages. Runx1 and its binding partner, CBF beta,, are frequently targeted in acute leukaemia but evidence is accumulating that all three Runx genes may have a role to play in a wider range of cancers, either as tumour promoters or tumour suppressors. Whilst Runx2 is renowned for its role as a master regulator of bone development we discuss here its expression pattern and putative functions beyond this lineage. Furthermore, we review the evidence that RUNX2 promotes neoplastic development in haematopoietic lineages and in advanced mammary and prostate cancer. (C) 2010 Elsevier Inc. All rights reserved.

引用

页码：117 / 123

页数：7

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