Belatacept conversion in an HIV-positive kidney transplant recipient following anti-thymocyte globulin induction

被引：4

作者：

Kuten, Samantha A. ^{[1
]}

Patel, Samir J. ^{[1
]}

Baru, Ashvin ^{[2
]}

Gaber, A. Osama ^{[3
]}

Crutchley, Rustin D. ^{[4
]}

Ramanathan, Venkataraman ^{[5
]}

Knight, Richard J. ^{[3
]}

机构：

[1] Houston Methodist Hosp, Dept Pharm, Houston, TX 77030 USA

[2] Austin Kidney Associates, Dept Nephrol, Austin, TX USA

[3] Houston Methodist Hosp, Dept Surg, Houston, TX USA

[4] Univ Houston, Coll Pharm, Dept Pharm, Houston, TX 77030 USA

[5] Baylor Coll Med, Dept Nephrol, Houston, TX 77030 USA

来源：

TRANSPLANT INFECTIOUS DISEASE | 2017年 / 19卷 / 05期

关键词：

belatacept; HIV; human immunodeficiency virus; kidney transplantation; HUMAN-IMMUNODEFICIENCY-VIRUS; UP-REGULATION; PHASE-III; BENEFIT; IMMUNOSUPPRESSION; CYCLOSPORINE; REGIMENS; OUTCOMES; INFECTION; REJECTION;

D O I：

10.1111/tid.12748

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Herein, we describe a case of early belatacept conversion in a human immunodeficiency virus (HIV)-positive kidney transplant recipient in an effort to improve suboptimal graft function and avoid drug interactions following anti-thymocyte globulin (ATG) administration. We observed improvement in renal function without HIV disease progression or opportunistic infections. Donor-specific antibodies appeared shortly after conversion but cleared without intervention. This case highlights belatacept as a means to improve renal function and avoid significant drug interactions even following ATG induction.

引用

页数：4

共 20 条

[1] Integrase strand transferase inhibitors: the preferred antiretroviral regimen in HIV-positive renal transplantation [J].

Azar, Marwan M. ;

Malinis, Maricar F. ;

Moss, J. ;

Formica, Richard N. ;

Villanueva, Merceditas S. .

INTERNATIONAL JOURNAL OF STD & AIDS, 2017, 28 (05) :447-458

[2]

Bray R, 2016, AM J TRANSPLANT, V16, P742

[3] Thymoglobulin-associated Cd4+ T-cell depletion and infection risk in HIV-infected renal transplant recipients [J].

Carter, JT ;

Melcher, ML ;

Carlson, LL ;

Roland, ME ;

Stock, PG .

AMERICAN JOURNAL OF TRANSPLANTATION, 2006, 6 (04) :753-760

[4] De Novo Belatacept in a Human Immunodeficiency Virus-Positive Kidney Transplant Recipient [J].

Cohen, E. A. ;

Mulligan, D. ;

Kulkarni, S. ;

Tichy, E. M. .

AMERICAN JOURNAL OF TRANSPLANTATION, 2016, 16 (09) :2753-2757

[5] A Phase III Study of Belatacept Versus Cyclosporine in Kidney Transplants from Extended Criteria Donors (BENEFIT-EXT Study) [J].

Durrbach, A. ;

Pestana, J. M. ;

Pearson, T. ;

Vincenti, F. ;

Garcia, V. D. ;

Campistol, J. ;

del Carmen Rial, M. ;

Florman, S. ;

Block, A. ;

Di Russo, G. ;

Xing, J. ;

Garg, P. ;

Grinyo, J. .

AMERICAN JOURNAL OF TRANSPLANTATION, 2010, 10 (03) :547-557

[6] Belatacept Conversion in an HIV-Positive Kidney Transplant Recipient With Prolonged Delayed Graft Function [J].

Ebcioglu, Z. ;

Liu, C. ;

Shapiro, R. ;

Rana, M. ;

Salem, F. ;

Florman, S. ;

Huprikar, S. ;

Nair, V. .

AMERICAN JOURNAL OF TRANSPLANTATION, 2016, 16 (11) :3278-3281

[7] Immunosuppressant pharmacokinetics and dosing modifications in HIV-1 infected liver and kidney transplant recipients [J].

Frassetto, L. A. ;

Browne, M. ;

Cheng, A. ;

Wolfe, A. R. ;

Roland, M. E. ;

Stock, P. G. ;

Carlson, L. ;

Benet, L. Z. .

AMERICAN JOURNAL OF TRANSPLANTATION, 2007, 7 (12) :2816-2820

[8] Upregulation of CTLA-4 by HIV-specific CD4+ T cells correlates with disease progression and defines a reversible immune dysfunction [J].

Kaufmann, Daniel E. ;

Kavanagh, Daniel G. ;

Pereyra, Florencia ;

Zaunders, John J. ;

Mackey, Elizabeth W. ;

Miura, Toshiyuki ;

Palmer, Sarah ;

Brockman, Mark ;

Rathod, Almas ;

Piechocka-Trocha, Alicja ;

Baker, Brett ;

Zhu, Baogong ;

Le Gall, Sylvie ;

Waring, Michael T. ;

Ahern, Ryan ;

Moss, Kristin ;

Kelleher, Anthony D. ;

Coffin, John M. ;

Freeman, Gordon J. ;

Rosenberg, Eric S. ;

Walker, Bruce D. .

NATURE IMMUNOLOGY, 2007, 8 (11) :1246-1254

[9] Costimulation Blockade Alters Germinal Center Responses and Prevents Antibody-Mediated Rejection [J].

Kim, E. J. ;

Kwun, J. ;

Gibby, A. C. ;

Hong, J. J. ;

Farris, A. B., III ;

Iwakoshi, N. N. ;

Villinger, F. ;

Kirk, A. D. ;

Knechtle, S. J. .

AMERICAN JOURNAL OF TRANSPLANTATION, 2014, 14 (01) :59-69

[10] Induction Immunosuppression and Clinical Outcomes in Kidney Transplant Recipients Infected With Human Immunodeficiency Virus [J].

Kucirka, L. M. ;

Durand, C. M. ;

Bae, S. ;

Avery, R. K. ;

Locke, J. E. ;

Orandi, B. J. ;

McAdams-DeMarco, M. ;

Grams, M. E. ;

Segev, D. L. .

AMERICAN JOURNAL OF TRANSPLANTATION, 2016, 16 (08) :2368-2376

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