Enantio- and Regioselective Iridium-Catalyzed Allylic Hydroxylation

被引：89

作者：

Gaertner, Martin ^{[1
]}

Mader, Steffen ^{[1
]}

Seehafer, Kai ^{[1
]}

Helmchen, Guenter ^{[1
]}

机构：

[1] Heidelberg Univ, Inst Organ Chem, D-69120 Heidelberg, Germany

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2011年 / 133卷 / 07期

关键词：

COMPLEXES-RESTING STATES; ENANTIOSELECTIVE SYNTHESIS; ASYMMETRIC-SYNTHESIS; SUBSTITUTION; CARBONATES; ETHERIFICATION; DERACEMIZATION; ALCOHOLS; RHODIUM; ESTERS;

D O I：

10.1021/ja109953v

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The first enantioselective allylic hydroxylation to prepare branched allylic alcohols directly is described. Bicarbonate was used as nucleophile in conjunction with new single component Ir-catalysts, which are stable to air and water. Excellent regio- and enantioselectivities have been achieved with a representative set of substrates.

引用

页码：2072 / 2075

页数：4

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