Synthesis and antimycobacterial activity of novel 4-[5-(substituted phenyl)-1-phenyl-4,5-dihydro-1H-3-pyrazolyl]-2-methylphenol derivatives

被引：3

作者：

Ali, Mohamed Ashraf ^{[1
]}

Yar, Mohammad Shahar ^{[1
]}

机构：

[1] Jamia Hamdard, Fac Pharm, Dept Pharmaceut Chem, New Delhi 110062, India

来源：

MEDICINAL CHEMISTRY RESEARCH | 2007年 / 15卷 / 09期

关键词：

D O I：

10.1007/s00044-007-9000-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In the present investigation, 4-hydroxy-3-methylacetophenone, on condensation with appropriate aldehydes in methanolic potassium hydroxide solution, yielded the corresponding chalcones (CI-XI). These corresponding chalcones were reacted with phenyl hydrazide in glacial acetic acid, which led to the formation of novel 4-[5-(substituted phenyl)-1-phenyl-4,5-dihydro-1H-3-pyrazolyll-2-methylphenol derivatives. All newly synthesized compounds were evaluated for their anti mycobacterial activities against isoniazid-resistant Mycobacterium tuberculosis using agar dilution. 4-[5-(4-Fluoro phenyl)-1-phenyl-4,5-dihydro-1H-3-pyrazolyl]-2-methylphenol showed good antimycobacterial activity, with a minimum inhibitory concentration of 0.62 mu g/ml.

引用

页码：463 / 470

页数：8