Effects of Insulin on Brain Glucose Metabolism in Impaired Glucose Tolerance

被引：97

作者：

Hirvonen, Jussi ^{[1
,2
,3
]}

Virtanen, Kirsi A. ^{[1
,2
]}

Nummenmaa, Lauri ^{[1
,2
,4
,5
]}

Hannukainen, Jarna C. ^{[1
,2
]}

Honka, Miikka-Juhani ^{[1
,2
]}

Bucci, Marco ^{[1
,2
]}

Nesterov, Sergey V. ^{[1
,2
,6
]}

Parkkola, Riitta ^{[3
]}

Rinne, Juha ^{[1
,2
]}

Iozzo, Patricia ^{[1
,2
,7
]}

Nuutila, Pirjo ^{[1
,2
]}

机构：

[1] Univ Turku, Turku PET Ctr, Turku, Finland

[2] Turku Univ Hosp, FIN-20520 Turku, Finland

[3] Univ Turku, Dept Radiol, Turku, Finland

[4] Aalto Univ, Sch Sci & Technol, Brain Res Unit, Low Temp Lab, Helsinki, Finland

[5] Aalto Univ, Sch Sci & Technol, Dept Biomed Engn & Computat Sci, Helsinki, Finland

[6] RAS, IM Sechenov Inst Evolutionary Physiol & Biochem, St Petersburg, Russia

[7] CNR, Inst Clin Physiol, Natl Res Council, I-56100 Pisa, Italy

来源：

DIABETES | 2011年 / 60卷 / 02期

基金：

芬兰科学院;

关键词：

RESISTANCE;

D O I：

10.2337/db10-0940

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

OBJECTIVE-Insulin stimulates brain glucose metabolism, but this effect of insulin is already maximal at fasting concentrations in healthy subjects. It is not known whether insulin is able to stimulate glucose metabolism above fasting concentrations in patients with impaired glucose tolerance. RESEARCH DESIGN AND METHODS-We studied the effects of insulin on brain glucose metabolism and cerebral blood flow in 13 patients with impaired glucose tolerance and nine healthy subjects using positron emission tomography (PET). All subjects underwent PET with both [F-18]fluorodeoxyglucose (for brain glucose metabolism) and [O-15]H2O (for cerebral blood flow) in two separate conditions (in the fasting state and during a euglycemic-hyperinsulinemic clamp). Arterial blood samples were acquired during the PET scans to allow fully quantitative modeling. RESULTS-The hyperinsulinemic clamp increased brain glucose metabolism only in patients with impaired glucose tolerance (whole brain: +18%, P = 0.001) but not in healthy subjects (whole brain: +3.9%, P = 0.373). The hyperinsulinemic clamp did not alter cerebral blood flow in either group. CONCLUSIONS-We found that insulin stimulates brain glucose metabolism at physiological postprandial levels in patients with impaired glucose tolerance but not in healthy subjects. These results suggest that insulin stimulation of brain glucose metabolism is maximal at fasting concentrations in healthy subjects but not in patients with impaired glucose tolerance. Diabetes 60:443-447, 2011

引用

页码：443 / 447

页数：5

共 25 条

[1] Attenuation of insulin-evoked responses in brain networks controlling appetite and reward in insulin resistance - The cerebral basis for impaired control of food intake in metabolic syndrome? [J].