Regulatory B lymphocyte functions should be considered in chronic lymphocytic leukemia

被引：17
作者：
Mohr, Audrey [1 ]
Renaudineau, Yves [1 ,2 ]
Bagacean, Cristina [1 ,2 ]
Pers, Jacques-Olivier [1 ]
Jamin, Christophe [1 ,2 ]
Bordron, Anne [1 ]
机构：
[1] Univ Brest, INSERM ESPRI ERI29 EA2216, Lab Immunotherapies & Pathol B Lymphocytes, Labex IGO,Rseau Epigenet & Reseau Canaux Ion Canc, Brest, France
[2] CHRU Morvan, Lab Immunol & Immunotherapy, Brest, France
来源：
ONCOIMMUNOLOGY | 2016年 / 5卷 / 05期
关键词：
B lymphocytes; CLL; immunotherapy; regulatory B cell; KILLER T-CELLS; INCREASED FREQUENCY; DENDRITIC CELLS; ALPHA-GALACTOSYLCERAMIDE; SUPPRESSIVE FUNCTION; GENE-EXPRESSION; GRANZYME-B; CPG ODN; DISEASE; CD1D;
D O I：
10.1080/2162402X.2015.1132977
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Chronic lymphocytic leukemia (CLL) is characterized by an abnormal expansion of mature B cells in the bone marrow and their accumulation in blood and secondary lymphoid organs. Tumor CLL cells share expression of various surface molecules with many subsets of B cells and have several common characteristics with regulatory B cells (B regs). However, the identification of B regs and their role in CLL remain elusive. The aim of this review is to summarize recent works regarding the regulatory and phenotypic characteristic of B regs and their associated effects on the immune system. It is also meant to highlight their potential importance with regards to the immunotherapeutic response.
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页数：10
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