Antimicrobial activity of aqueous and solvent extracts of Adina cordifolia, Careya arborea, Careya arborea, Hiptage benghalensis and Lannea coromandelica were tested against different bacteria (Bacillus cereus, Bacillus subtilis, Staphylococcus aureus, Streptococcus pyogenes, Enterobacter aerogenes, Escherichia coli, Proteus mirabilis, Klebsiella pneumonia) and fungi (Fusarium oxysporum, Aspergillus niger, Curvularia lunata and Alternaria alternata). Out of the tested plants, Cassia angustifolia and Adina cordifolia were found effective in inhibiting the growth of test microorganisms. Ethanol extract of C. angustifolia exhibited the maximum antibacterial potential with 24.66 mm inhibition zone of against S. aureus followed by E.coli (22.62 mm), B. subtilis (21.63 mm), E. aerogenes (18.32 mm), K. Pneumonia (17.67 mm) and B. cereus with 15.00 mm of inhibition. Aqueous extract of C. angustifolia showed maximum growth inhibition against B. cereus with inhibition zone of 21.55 mm followed by B. sublilis (19.47 mm) and E. coif (16.32 mm). A. cordifolia was found effective against B. cereus (15.52 mm), S. aureus (10.49 mm) and E.coli (11.32 mm). Against test fungi, C.angustifolia was found potent against F. oxysporum with 60 % of mycelial inhibition followed 13.16 % of inhibition against A. alternate. Ethanol extract of C. angustifolia exhibited the strong antifungal potential against C. lunata with 22.93 mm zone of inhibition.